Genetics of Severe Obesity

AbstractPurpose of ReviewThis review aims to present current information on genes underlying severe obesity, with the main emphasis on the three genesLEP,LEPR andMC4R.Recent FindingsThere is a substantial amount of evidence that variants in at least ten different genes are the cause of severe monogenic obesity. The majority of these are involved in the leptin-melanocortin signalling pathway. Due to the frequency of some of the identified variants, it is clear that monogenic variants also make a significant contribution to common obesity.SummaryThe artificial distinction between rare monogenic obesity and common polygenic obesity is now obsolete with the identification ofMC4R variants of strong effect in the general population.
Source: Current Diabetes Reports - Category: Endocrinology Source Type: research