Synthesis and Characterization of Photocatalytic Polyurethane and Poly(Methyl Methacrylate) Microcapsules for the Controlled Release of Methotrexate.

Synthesis and Characterization of Photocatalytic Polyurethane and Poly(Methyl Methacrylate) Microcapsules for the Controlled Release of Methotrexate. Drug Dev Ind Pharm. 2018 Aug 16;:1-21 Authors: Al-Nemrawi NK, Marques J, Tavares CJ, Oweis RJ, Al-Fandi MG Abstract The aim of this work is to prepare ultraviolet (UV) triggered controlled release of compounds from microcapsule systems (MCs). Polyurethane (PU) and poly(methyl methacrylate) (PMMA) microcapsules were studied with/without chemical functionalization using photocatalytic TiO2 nanoparticles (NPs) on their surface. Once TiO2 nanoparticles are illuminated with UV light (λ = 370nm) they initiate the rupture of the polymeric bonds of the microcapsule and subsequently initiate the encapsulated compound release, methotrexate (MTX) or rhodamine (Rh), in the present work. The size, polydispersity, charge and yield of all MCs was measured, being the methotrexate drug release for all systems determined and compared with and without functionalization with TiO2 NPs, under dark, visible light and UV illumination in vitro. Finally, the Rh release was characterized using fluorescence microscopy. The TiO2 NPs size is around 10nm, as determined by X-ray diffraction experiments. The PU MCs average size is around 60µm, its electric charge +3.11mV and yield around 85%. As for the PMMA MCs, the average size is around 280µm, its electric charge -7.2mV and yield around 25% and 30% for both MTX a...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research