Photo-responsive nanoparticles for β-lapachone delivery in vitro

Publication date: September 2018Source: Chinese Chemical Letters, Volume 29, Issue 9Author(s): Huibo Li, Changmai Chen, Qin An, Guoyan Huo, Mingtao RunAbstractDrug efficiency delivery and release to target site play an important role in the treatment of cancer. To achieve these goals, developing drug delivery systems is the key step. The common materials used for drug delivery like liposomes, micelles, dendrimers cannot control the delivery and releasing by spatial and temporal. In this paper, we design a photoresponsive drug delivery system to reduce the side effects of traditional chemotherapy on normal cells and improve therapeutic efficacy in treating cancers. We synthesized two kinds of photo-responsive polymers using two different monomers containing two photoresponsive groups. The two monomers were crosslinked by poly (ethylene glycol) dimethacrylate to form polymers and then encapsulated β-lapachone into the nanoparticles, after UV irradiation, the particle will degrade and release the drug. This method may provide new strategies for the photoresponsive nanomaterials.Graphical abstractThe figures A and B shows the size contribution of two photoresponsive nanoparticles (before, red and after UV irradiation, green), after UV irradiation, the particle size swell large than without UV irradiation, but not very much, which may cause low cell toxicity.
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research