Metabolites of prostaglandin synthases as potential biomarkers of Lyme disease severity and symptom resolution

ConclusionDysregulation of prostaglandins and related lipid mediators may play a role in the etiology of LB and persistence of inflammation that may lead to long-term complications. Further investigation into the precise levels of a wide range of PGs and related factors is critical as it may propose novel markers that can be used for early diagnosis.
Source: Inflammation Research - Category: Research Source Type: research

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Rheumatoid is a long-term joint condition that affects more than 400,000 people in the UK. It currently has no cure research shows that specific foods can alleviate symptoms.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
KATE GARRAWAY returns to ITV's Good Morning Britain on Monday morning, after a period away from the TV show to be with her husband, as he continues his recovery from coronavirus. But, the GMB presenter was rushed to hospital herself last year. Would you recognise the signs and symptoms of meningitis?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Source: Epigenetics - Category: Genetics & Stem Cells Authors: Source Type: research
AbstractPurposeTo determine whether patient demographics have predictive influence on patient-reported outcomes measurement information system (PROMIS) domains of pain interference (PROMIS-PI), depression (PROMIS-D), and upper extremity (PROMIS-UE) for patients with shoulder pathology treated nonoperatively.MethodsPatients with partial rotator cuff tears, impingement, scapular dyskinesia, osteoarthritis, muscle strains, biceps tendonitis, instability, and acromioclavicular arthritis were retrospectively identified. Patients who underwent surgery were excluded. Demographic characteristics were documented, and PROMIS scores ...
Source: Musculoskeletal Surgery - Category: Orthopaedics Source Type: research
Nature Reviews Neurology, Published online: 13 July 2020; doi:10.1038/s41582-020-0374-yThis Review discusses the advantages and pitfalls of metagenomic next-generation sequencing (mNGS) in patients with encephalitis, meningitis and myelitis. The authors outline data on mNGS test performance, cost and turnaround time and highlight future directions for mNGS technology.
Source: Nature Reviews Neurology - Category: Neurology Authors: Source Type: research
ConclusionSeveral juvenile idiopathic arthritis-relevant MRI characteristics can be observed in the clinically non-inflamed symptomatic pediatric wrist.
Source: Pediatric Radiology - Category: Radiology Source Type: research
This study integrated three expression profile datasets (GSE55235, GSE12021, and GSE55457) and one methylation profile dataset GSE111942 to elucidate the potential essential candidate genes and pathways in RA. Differentially expressed genes (DEGs) and differentially methylation genes (DMGs) were identified by R programming software, using Limma package and ChAMP package, respectively. DAVID performed gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analysis of DEGs. Functional annotation and construction of a protein-protein interaction (PPI) network and the Molecular Complex Detect...
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
For most of us, springtime marks the return of life to a dreary landscape, bringing birdsong, trees in bud, and daffodils in bloom. But if you work for the Centers for Disease Control and Prevention (CDC), the coming of spring means the return of nasty diseases spread by ticks and mosquitoes. The killjoys at CDC celebrated the end of winter with a bummer of a paper showing that infections spread by ticks doubled in the United States from 2004 to 2016. (Tick populations have exploded in recent decades, perhaps due to climate change and loss of biodiversity.) Lyme disease The most common infection spread by ticks in the US i...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Source Type: blogs
is the most common tick-borne illness in the USA and Europe. Pathogens involved are Borrelia burgdorferi in the USA and B. afzelii and B. garinii in Europe. The characteristic rash of erythema migrans occurs in approximately 75% of patients. Neurological disease, including facial palsy, meningoencephalitis, aseptic meningitis and polyradiculopathy, occurs in 10 –15%. Cardiac disease, primarily manifest as heart block, is seen in 1–2%. Arthritis is seen as a late complication in about 30%.
Source: Medicine - Category: Internal Medicine Authors: Tags: Bacterial infections Source Type: research
Conclusions. In this low-prevalence cohort, fewer than 20% of positive Lyme disease tests are obtained from patients with clinically likely Lyme disease. Positive Lyme disease test results may have little diagnostic value in this setting.
Source: Clinical Infectious Diseases - Category: Infectious Diseases Authors: Tags: ARTICLES AND COMMENTARIES Source Type: research
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