Metabolites of prostaglandin synthases as potential biomarkers of Lyme disease severity and symptom resolution

ConclusionDysregulation of prostaglandins and related lipid mediators may play a role in the etiology of LB and persistence of inflammation that may lead to long-term complications. Further investigation into the precise levels of a wide range of PGs and related factors is critical as it may propose novel markers that can be used for early diagnosis.
Source: Inflammation Research - Category: Research Source Type: research

Related Links:

Discussion The mandible normally grows in a symmetric downward and forward movement relative to the skull base. The condyle is the primary growth center. “The mandible is unique in that its 2 joints and growth centers function together as a single unit.” It is the last bone in the body to reach skeletal maturity. The mandible and its growth are important for maxillary growth and therefore many problems that affect the mandible affect the facial and skulls structures as well. These growth problems can be relatively insidious and therefore may need monitoring over longer periods of time such as patients with unde...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
AbstractContinued low-dose MMI treatment for longer than 12 –18 months may be considered in patients not in remission. However, ATDs are not free from adverse effects. We undertook a systematic review to clarify safety of long-term ATD treatment. Medline and the Cochrane Library for trials published between 1950 and Nov 2018 were systematically searched. We included original studies containing data for long-term (>  18 months) ATD treatment. Two reviewers independently extracted data from included trials and any disagreement was adjudicated by consensus. Of 615 related articles found, 12 fulfilled...
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Called APPA, the pill is based on anti-inflammatory compounds found in peonies – flowers that brighten up flowerbeds in late spring and summer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
This study not only provides prompts to the researcher who explores pharmacological and biological molecular mechanism of TWH applying to RA disease, but also proves a feasible method for discovering potential activated compounds from Chinese herbs. PMID: 31118961 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
LYME disease is a relatively unknown condition with an estimated 2,000 to 3,000 new cases each year in England and Wales. For an unknown disease however, anyone can develop the condition as its caught by a tick. This major symptom could mean you might have Lyme disease. Do you have it?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
A required postmarketing clinical trial of tofacitinib (Xeljanz, Xeljanz XR) in the treatment of rheumatoid arthritis found an increased risk of pulmonary embolism and death when patients were treated with 10 mg twice daily compared with the currently approved 5 mg twice daily dose.NPs are encouraged to follow tofacitinib's dosing guidelines when treating rheumatoid arthritis.
Source: AJN - Category: Nursing Tags: Drug Watch Source Type: research
For most of us, springtime marks the return of life to a dreary landscape, bringing birdsong, trees in bud, and daffodils in bloom. But if you work for the Centers for Disease Control and Prevention (CDC), the coming of spring means the return of nasty diseases spread by ticks and mosquitoes. The killjoys at CDC celebrated the end of winter with a bummer of a paper showing that infections spread by ticks doubled in the United States from 2004 to 2016. (Tick populations have exploded in recent decades, perhaps due to climate change and loss of biodiversity.) Lyme disease The most common infection spread by ticks in the US i...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Infectious diseases Source Type: blogs
is the most common tick-borne illness in the USA and Europe. Pathogens involved are Borrelia burgdorferi in the USA and B. afzelii and B. garinii in Europe. The characteristic rash of erythema migrans occurs in approximately 75% of patients. Neurological disease, including facial palsy, meningoencephalitis, aseptic meningitis and polyradiculopathy, occurs in 10 –15%. Cardiac disease, primarily manifest as heart block, is seen in 1–2%. Arthritis is seen as a late complication in about 30%.
Source: Medicine - Category: Internal Medicine Authors: Tags: Bacterial infections Source Type: research
Conclusions. In this low-prevalence cohort, fewer than 20% of positive Lyme disease tests are obtained from patients with clinically likely Lyme disease. Positive Lyme disease test results may have little diagnostic value in this setting.
Source: Clinical Infectious Diseases - Category: Infectious Diseases Authors: Tags: ARTICLES AND COMMENTARIES Source Type: research
More News: Arthritis | Lyme Disease | Men | Meningitis | Research | Rheumatology | Study