P137 Joint estimation of radiation-induced late toxicity and cancer recurrence risks for bilateral breast cancer after photon versus spot-scanning proton therapy

Joint estimation of risks of radiation-induced secondary lung cancer (SLC) and ischemic heart disease (IHD) modeled with consideration of patient-level risk factors and risk of cancer recurrence caused by compromising target coverage.
Source: Physica Medica: European Journal of Medical Physics - Category: General Medicine Authors: Source Type: research

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In this study, we hypothesized that moderately and chronically reducing ACh could attenuate the deleterious effects of aging on NMJs and skeletal muscles. To test this hypothesis, we analyzed NMJs and muscle fibers from heterozygous transgenic mice with reduced expression of the vesicular ACh transporter (VAChT), VKDHet mice, which present with approximately 30% less synaptic ACh compared to control mice. Because ACh is constitutively decreased in VKDHet, we first analyzed developing NMJs and muscle fibers. We found no obvious morphological or molecular differences between NMJs and muscle fibers of VKDHet and contro...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: Available online 7 September 2019Source: Preventive MedicineAuthor(s): Giulia Carreras, Alessandra Lugo, Silvano Gallus, Barbara Cortini, Esteve Fernández, Maria José López, Joan B. Soriano, Ángel López Nicolás, Sean Semple, Giuseppe Gorini, Yolanda Castellano, Marcela Fu, Montse Ballbè, Beladenta Amalia, Olena Tigova, Xavier Continente, Teresa Arechavala, Elisabet Henderson, Alessandra Lugo, Xiaoqiu LiuAbstractOur aim was to provide a systematic review of studies on the burden of disease due to second-hand smoke (SHS) exposure, reviewing methods, exposure ...
Source: Preventive Medicine - Category: International Medicine & Public Health Source Type: research
This study aimed to reduce the risk of cardiovascular events through an optimization of the dose distribution on heart substructures in mediastinal HL patients with the adoption of different volumetric modulated arc therapy (VMAT) techniques, while maintaining the same risk of second cancer induction on lungs and breasts. MATERIALS AND METHODS: Thirty patients (15 males and 15 females, 15 bulky lesions) treated between 2012 and 2017 at our institution were selected. Disease extent was mediastinum plus neck (n = 10), mediastinum plus unilateral axilla (n = 10) and mediastinum alone (n = 10). Lungs, breasts,...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
Conclusions: We successfully designed and synthesized a novel radiotracer 68Ga-NOTAGA-GAP19 that targets Connexin43. Experiments in vitro demonstrated that the molecular probe 68Ga-NOTAGA-GAP19 can bind to Connexin43 in non-small cell lung cancer cell lines. Further research on this probe is necessary to verify its stability and imaging effect in vivo.Reference: [1] Schulz R, Gorge PM, Gorbe A, Ferdinandy P, Lampe PD, and Leybaert L. Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection. Pharmacol Ther. 2015;153:90-106. [2] Grek CL, Rhett JM, Bruce JS, Ghatnekar ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Radiochemistry & amp; Chelation Posters Source Type: research
Conclusions and Perspectives In this review, we have discussed important milestones from the early description of “Serum-sickness” as being due to antibodies directed against Neu5Gc epitopes all the way to the present-day therapeutic implications of these antibodies in cancer therapy. Some of these milestones have been represented in a concise timeline (Figure 6). While the “Xenosialitis” hypothesis is well-supported in the human-like mouse models, it has yet to be conclusively proven in humans. It remains to be seen if “Xenosialitis” plays a role in other uniquely-human diseases. FI...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Rayfield Byrd knows when it’s time to wake up every morning. The 68-year-old Oakland, Cal., resident hears a voice from the living room offering a cheery good morning. Except Byrd lives alone. A little after 8 a.m. each day, a small yellow robot named Mabu asks Byrd how he’s doing. Byrd has Type 2 diabetes and congestive heart failure, and about three years ago, he had surgery to implant a microvalve in his heart to keep his blood flowing properly. To stay healthy, he takes four medications a day and needs to exercise regularly. To make sure his heart is still pumping effectively, his doctor needs to stay on to...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Artificial Intelligence Life Reinvented medicine Source Type: news
The headlines are once again filled with advice to reduce egg and cholesterol consumption based on a study that found an association of egg and cholesterol consumption with increased risk for cardiovascular events. Sounds scary and persuasive, doesn’t it? After all, nearly 30,000 people were tracked over 17 years and the authors authoritatively declare that this proves that eggs and cholesterol are risk factors for heart disease. There are several problems with this assessment. It is emblematic of the studies that confuse people, yield wildly conflicting conclusions, are used to craft absurd and ineffective dietary g...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates cholesterol eggs grain-free saturated fat undoctored wheat belly Source Type: blogs
U.S. and Guatemalan healthcare institutions are collaborating to bring radiation...Read more on AuntMinnie.comRelated Reading: Cancer rates rising in lower-income countries Breast cancer on rise in low-income countries Breast cancer risk profiles differ in developing nations Air pollution tied to lung cancer, heart disease WHITIA scores win with Guatemala digital x-ray install
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Mortality rates for cancer have diminished slowly and steadily over the past few decades. This is a matter of prevention on the one hand and improvements in early detection of cancer on the other. When caught early enough, even comparatively crude approaches to therapy have a decent chance of controlling and eliminating the cancer. This trend will no doubt continue, but the more rapid, more effective progress that we'd like to see will only emerge given the advent of universal cancer therapies, those that strike at mechanisms, such as telomere lengthening, that are shared by many or all cancers. That is a plausible goal fo...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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