Comparative utility of NRG and NRGS mice for the study of normal hematopoiesis, leukemogenesis and therapeutic response

Immune deficient mice have revolutionized biomedical research, including the study of both normal human hematopoiesis and leukemogenesis.[1-3] Capable of harboring both normal and malignant human xenografts without rejection, highly immune deficient mice are indispensable in hematological research allowing differentiation and proliferation of these cells in vivo.[4] Xenograft mouse models consistently better predict the success of experimental chemotherapeutics in clinical trials [5], likely due to the complex and dynamic interaction between the bone marrow (BM) microenvironment and heterogeneous populations of leukemic cells.

Source: Experimental Hematology - August 17, 2018 Category: Hematology Authors: Aditya Barve, Lavona Casson, Maxwell Krem, Mark Wunderlich, James C. Mulloy, Levi J. Beverly Source Type: research