Assessing Antimicrobial Stewardship Initiatives: Clinical Evaluation of Cefepime or Piperacillin-tazobactam in Patients with Bloodstream Infections Secondary to AmpC Producing Organisms

The increasing threat of antibiotic resistance amongst Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter spp. identified in healthcare-associated infections is a grave public health concern [1]. Amongst the Enterobacteriaceae, AmpC beta-lactamases present a unique challenge. Commonly found on chromosomes and plasmids in Enterobacter spp, Serratia spp., Pseudomonas aeruginosa, Acinetobacter spp., and Citrobacter spp., their presence raises concern due to rapid hydrolysis of commonly used antibiotics such as penicillins, second and third-generation cephalosporins, and monobactams [2,3].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research