Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders

Although several studies have found reduced plasma BDNF levels in patients with severe mental disorders, the sample sizes have been small and have exhibited variation and heterogeneity. Furthermore, long-term neurobiological changes following childhood trauma and clinical severity have been linked to a reduction in BDNF levels. Accordingly, we aim to clarify, using the largest sample size to date, the role of plasma BDNF in individuals with severe mental disorders in relation to the number of episodes, current remission status, and childhood trauma experiences.

Source: Schizophrenia Research - August 17, 2018 Category: Psychiatry Authors: Monica Aas, Ingrid Dieset, Ragni M ørch, Nils Eiel Steen, Sigrun Hope, Elina J. Reponen, Jannicke F. Laskemoen, Thor Ueland, Pål Aukrust, Ingrid Melle, Ingrid Agartz, Ole A. Andreassen Source Type: research