Concerns about bias in studies on clozapine and mortality

In view of the high all-cause mortality among patients with schizophrenia and the wide range of positive and negative effects of clozapine, it is important to know whether the drug is associated with a differential mortality pattern in comparison to other antipsychotic drugs. Tiihonen et al. (2009) reported a significantly lowered all-cause mortality and a lowered mortality from suicide in users of clozapine. In this journal, however, de Hert et al. (2010) pointed out that several types of bias may have influenced the results.
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the Editor Source Type: research