A new approach for Alzheimer's Disease treatment through P-gp regulation via ibuprofen

In conclusion, the P-gp expression and function were suppressed in AD condition by activating inflammatory reaction, and then causing the Aβ efflux decreased. However, upregulating P-gp could increase the Aβ efflux in further to treat AD via inhibiting the inflammatory factors expression.
Source: Pathology Research and Practice - Category: Pathology Source Type: research