Stocking EpiPens at Restaurants Might Reduce Fatal Allergic Reactions Stocking EpiPens at Restaurants Might Reduce Fatal Allergic Reactions

If restaurants and other food establishments stocked epinephrine autoinjectors, the number of fatal allergic reactions, known as anaphylaxis, could decrease, a small study in Canada suggests.Reuters Health Information
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news

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ConclusionsPrompt epinephrine treatment is crucial. Use of antihistamines in conjunction with epinephrine may reduce the risk of uncontrolled reactions (administration of 2 or more doses of epinephrine in the ED), although our findings do not support the use of corticosteroids.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
CONCLUSION: Despite implementation of a PDR, dosing errors, including ten-fold errors, still occur at a high rate. Errors occur with dilution and length-based tape use. Further error reduction strategies, beyond a PDR and that target errors of omission, are needed for pediatric prehospital drug administration. PMID: 31084508 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research
Authors: Mantovani A, Álvares-Da-Silva MR Abstract A 63-year-old female patient with recent diagnosis of hepatitis C and cirrhosis and no other comorbidities, on no medications, was found to have Barcelona Clinic Liver Cancer stage C hepatocellular carcinoma and began systemic therapy with sorafenib 400mg twice daily. Five days after starting treatment, the patient went to an emergency department with pruritic, target-shaped, erythematous papules compatible with erythema multiforme, painful oral aphthous ulcers, and fever. Sorafenib was suspended and the patient underwent oral corticosteroid treatment for 5 ...
Source: Annals of Hepatology - Category: Gastroenterology Tags: Ann Hepatol Source Type: research
ConclusionDespite increased rates of caesarean delivery in USA and consequent drug administration, there was no evidence of an increasing trend in anaphylaxis. Caesarean delivery and prior history of an allergic reaction allow the identification of women at risk of anaphylaxis. Not all women had clear risk factors and preparations should always be in place to ensure timely management if this uncommon event occurs.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Recently, new diagnostic tools and therapeutic agents have significantly increased the survival rate of cancer patients compared to that in the past. As the number of cancer survivors exposed to multiple courses of chemotherapy increases, more patients become sensitized to chemotherapeutic agents and suffer from hypersensitivity reactions (HSRs).1-3 HSRs to chemotherapeutic agents range from mild cutaneous urticaria to severe reactions, such as life-threatening anaphylaxis, and even death.4 Most HSRs are unpredictable, such that they threaten the safety of patients; moreover, they can be uncontrollable, and severe HSRs lim...
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Source Type: research
Abstract Drug allergies occur when hapten-like drug metabolites conjugated to serum proteins, through their interactions with specific IgE, trigger allergic reactions that can be life threatening. A molecule termed covalent heterobivalent inhibitor (cHBI) was designed to specifically target drug hapten-specific IgE to prevent it from binding drug-haptenated serum proteins. cHBI binds the two independent sites on a drug hapten-specific Ab and covalently conjugates only to the specific IgE, permanently inhibiting it. The cHBI design was evaluated via ELISA to measure cHBI-IgE binding, degranulation assays of rat bas...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
Condition:   Anaphylaxis Intervention:   Sponsor:   Groupe Hospitalier Paris Saint Joseph Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Purpose of review To provide an updated framework of management for allergic emergencies. Recent findings The most frequent causes of anaphylaxis include medications, foods, and stinging insects. Early and appropriate administration of epinephrine is critical to managing anaphylaxis. Although epinephrine is well tolerated and there is no absolute contraindication to using epinephrine in first-aid management of anaphylaxis, many patients at risk for anaphylaxis still fail to carry and use the medication prior to seeking emergency care. Outcomes of allergic emergencies can be improved by educational efforts that focus o...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: OFFICE PEDIATRICS: Edited by Henry H. Bernstein Source Type: research
AbstractThe clinical threshold in wheat-dependent, exercise-induced anaphylaxis seems to be lowered in patients on wheat free diet, whereas the opposite is seen in patients on regular wheat intake. Therefore, a recommendation of wheat consumption, if considered safe to the patient based on case-history and challenge results, could be advised.
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
Conclusions: SA suppresses mast cell–mediated allergic response by blocking the Lyn–FcεRIβ interaction in vitro and in vivo. SA may be a promising therapeutic agent for allergic and other mast cell–related diseases.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
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