RCAN1 is a marker of oxidative stress, induced in acute pancreatitis

To date, there still is a lack of specific acute pancreatitis markers and specifically an early marker that can reliably predict disease severity. The inflammatory response in acute pancreatitis is mediated in part through oxidative stress and calcineurin-NFAT (Nuclear Factor of Activated T-cells) signaling, which is inducing its own negative regulator, regulator of calcineurin 1 (RCAN1). Caerulein induction is a commonly used in vivo model of experimental acute pancreatitis. Caerulein induces CN-NFAT signaling, reactive oxygen species and inflammation.

Source: Pancreatology - August 16, 2018 Category: Gastroenterology Authors: K. Jessica Norberg, Salvatore Nania, Xuan Li, Hui Gao, Peter Szatmary, Ralf Segersv ärd, Stephan Haas, Annika Wagman, Urban Arnelo, Robert Sutton, Rainer L. Heuchel, J. Matthias Löhr Source Type: research