Adolescent Δ9-THC exposure and astrocyte-specific genetic vulnerability converge on NF-κB-COX-2 signaling to impair memory in adulthood

Although several studies linked adolescent cannabis use to long-term cognitive dysfunction, there are negative reports too. The fact that not all users develop cognitive impairment suggests a genetic vulnerability to adverse effects of cannabis, which are attributed to action of delta-9-tetrahydrocannabinol ( Δ9-THC), a cannabis constituent and partial agonist of brain cannabinoid receptor 1 (CNR1). As both neurons and glial cells express CNR1, genetic vulnerability could influence Δ9-THC-induced signaling in a cell type-specific manner.

Source: Biological Psychiatry - August 16, 2018 Category: Psychiatry Authors: Yan Jouroukhin, Xiaolei Zhu, Alexey V. Shevelkin, Yuto Hasegawa, Bagrat Abazyan, Atsushi Saito, Jonathan Pevsner, Atsushi Kamiya, Mikhail V. Pletnikov Tags: Priority Communication Source Type: research