Digital Technologies for Improving Hygiene in Health Facilities

150 years after Semmelweis advised fellow physicians to sanitize their hands to mitigate the effect of infections, the maintenance of hygiene is still a widespread problem in hospitals and the source of healthcare-associated infections. Now, technological solutions line up against microorganisms, bacteria, and fungi. Here are a few examples. 1 in 9 in-patients will die due to infection According to the US Center for Disease Control, studies show that on average, healthcare providers clean their hands less than half of the times they should. This significantly contributes to the spread of healthcare-associated infections (HAIs or HCAIs), such as MRSA (methicillin-resistant Staphylococcus aureus) and C. diff (Clostridium difficile), affecting 1 in 25 hospital patients on any given day. Statistics revealed that on average, 1 in 9 will die due to the infection, and the number of HAI caused the death of approximately 99,000 people in 2002 only in the US. That’s almost the population of Seychelles. Still, that was only the extent of the problem in one country. The World Health Organization estimates that there are over 1.4 million cases of HAI at any given time. Of every 100 hospitalized patients, 7 in developed and 10 in developing countries will acquire at least one healthcare-associated infection. However, this is likely to be a gross underestimation, due to the lack of proper surveillance. These are insanely high numbers, especially considering that Dr. Ignác Semme...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Healthcare Design Medical Professionals Policy Makers clean digital digital health future HAI healthcare-associated infection hygiene Medicine robot robotics sensors technology trackers wearable Source Type: blogs

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New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C9NJ03462E, PaperRajkumar Reddyrajula, Udayakumar Dalimba Ambien (zolpidem) is an imidazo[1,2-a]pyridine derivative, a commercial drug to treat insomnia which also possesses the antitubercular activity against Mycobacterium tuberculosis H37Rv. In this paper, we describe the synthesis of... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Source: Clinical Epidemiology - Category: Epidemiology Tags: Clinical Epidemiology Source Type: research
Publication date: Available online 17 September 2019Source: Microbes and InfectionAuthor(s): Sophia HäfnerAbstractArticle highlight based on “VraSR has an important role in immune evasion of Staphylococcus aureus with low level vancomycin resistance" by Caihong Gao et al.
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Publication date: 30 October 2019Source: International Journal of Pharmaceutics, Volume 570Author(s): Bhamini Rangnekar, Mohammad A.M. Momin, Basanth Babu Eedara, Shubhra Sinha, Shyamal C. DasAbstractDrug-resistant tuberculosis (DR-TB) is an emerging health problem, challenging the effective control of global TB. Current treatment of DR-TB includes administration of multiple anti-TB drugs via oral and parenteral routes for a duration of 20–28 months. High systemic exposure, side effects and lengthy treatment time are problems affecting current treatment. The success rate of current lengthy treatment regimens is gen...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 18 September 2019Source: Drug Discovery Today: Disease ModelsAuthor(s): Allan Artavia-León, Miguel Pacheco-Leiva, Cristofer Moya-Román, Natalia Rodríguez-Hernández, Adrián A. Pinto-TomásAnts have been widely studied, with 14,000 described species, but it is not until recently that they gained attention as sources for antimicrobial drug discovery. An increasing amount of studies are investigating ant-microbe symbioses, and clear benefits from their microbial counterparts have been experimentally demonstrated for ants in the tribes Attini, Camponoti...
Source: Drug Discovery Today: Disease Models - Category: Drugs & Pharmacology Source Type: research
Publication date: 1 December 2019Source: Materials Letters, Volume 256Author(s): P. Ramesh, S. Sambathkumar, R. Jagatheesan, S. Vasanth KumarAbstractIn this case, a facile synthesis of alcohol functionalized graphene oxide (GO) material has been made using water soluble, non-toxic, biocompatible tris buffer (TB) and diethenolamine (DEA). This functional material was characterized by various techniques such as, XRD, TEM, XPS, Raman, TGA and Cyclic voltametry (CV). The molecular level grafting of amines to graphene has been occurred due to the functionalization of alcohol by the enlargement of interlayer spacing and specific...
Source: Materials Letters - Category: Materials Science Source Type: research
Publication date: 17 September 2019Source: Cell Reports, Volume 28, Issue 12Author(s): Krishna C. Chinta, Md. Aejazur Rahman, Vikram Saini, Joel N. Glasgow, Vineel P. Reddy, Jeremie M. Lever, Shepherd Nhamoyebonde, Alasdair Leslie, Ryan M. Wells, Amie Traylor, Rajhmun Madansein, Gene P. Siegal, Veena B. Antony, Jessy Deshane, Gordon Wells, Kievershen Nargan, James F. George, Pratistadevi K. Ramdial, Anupam Agarwal, Adrie J.C. Steyn
Source: Cell Reports - Category: Cytology Source Type: research
Abstract 1-Chloro-2-hydroxy-3-butene (CHB) is a possible metabolite of 1,3-butadiene, a carcinogenic air pollutant. To demonstrate its formation in vivo, it is desirable to develop a practical biomarker and the corresponding analysis method. CHB can undergo alcohol dehydrogenase- and cytochromes P450 enzymes (P450)-mediated oxidation to yield 1-chloro-3-buten-2-one (CBO), which readily forms glutathione conjugates. We hypothesized that CBO-derived mercapturic acids, which are the expected biotransformed products of CBO-glutathione conjugates, could be used as CHB biomarkers. Thus, in the present study, we investig...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
Abstract Methicillin-susceptible S. aureus changes to methicillin-resistant S. aureus (MRSA) upon the acquisition of staphylococcal cassette chromosome mec (SCCmec), a genomic island that encodes methicillin resistance. SCCmec elements in S. aureus are classified into different types based on the combination of mec gene complexes and ccr gene complexes, which share variations, five classes in mec and eight in ccr. To date, at least 13 types of SCCmec elements have been identified and each SCCmec type has individual characteristics. It is known that hospital-associated MRSA strains carry SCCmec elements of types, I...
Source: Molecular Medicine - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
WEDNESDAY, Sept. 18, 2019 -- An estimated 12.6 million persons in the United States could benefit from treatment to prevent active tuberculosis (TB), according to a report published in the October issue of Emerging Infectious Diseases, a publication...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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