Young Patients with Colorectal Cancer: Risk, Screening, and Treatment
AbstractPurpose of ReviewWhile the incidence and mortality of colorectal cancer have been declining in the USA in the last decades, there is a considerable increase in the incidence of this malignancy in the young adult patients. Several environmental and genetic factors have been studied and known to be associated with colorectal cancer. However, the exact causes of this increase are not clear. Therefore, in this review, we aimed to provide insights in terms of novel findings and avenues of research that may lead to a better way to treat this population of patients.Recent FindingsObesity and its associated behaviors, such as unhealthy dietary patterns and sedentary lifestyles, as well as gut microbiota may play a crucial role in colorectal cancer (CRC) risk for young adults. Recently, the American Cancer Society recommends that adults aged 45 years and older with an average risk of CRC undergo regular screening with either a high-sensitivity stool-based test or a structural examination, depending on patient preference and test availability. It is important to note that data on outcomes associated with systemic cytotoxic and biologic th erapy specifically in young patients with CRC are lacking.SummaryIn this review, we provide an overview on the most recent evidence regarding incidence, screening, molecular features, and management of young patients with colorectal cancer.
ConclusionsHigh-risk advanced adenomas are predominantly left sided. This focuses attention on the rectum and left colon where carcinogenesis is strong in the young.
FRIDAY, Dec. 20, 2019 -- Diagnosis and treatment of young adults with colon cancer improved under an Affordable Care Act (ACA) provision permitting young adults up to age 26 to be covered under their parents'insurance, researchers report. They...
(American Cancer Society) An Affordable Care Act provision that allowed young adults to be covered under their parents' insurance led to a shift to earlier-stage diagnosis and more timely receipt of adjuvant chemotherapy among young colorectal cancer patients, according to a new American Cancer Society study. The study appears in JNCI.
CONCLUSION: Molecular profiling of AYA CRC revealed different molecular characteristics in RT versus LT. Epigenetic mechanisms and alteration in DNA repair genes warrant further investigation and may be a promising treatment target for CRC in AYA. IMPLICATIONS FOR PRACTICE: Colorectal cancer (CRC) in adolescents and young adults (AYA) comprises a distinct entity with different clinicopathologic features and prognosis compared with older patients. Molecular profiling of right- and left-sided tumors in AYA is needed to gain novel insight into CRC biology and to tailor targeted treatment in this age group. This study fou...
Conclusions: We found age-related disparities in CRC incidence and IBM between individuals under age 50 and age 50 years and older. Increasing incidence rates of rectal cancer substantially accounts for this disparity among individuals under age 50. The escalating trends of early-onset CRC warrant investigation into the factors leading to the population-level trends. PMID: 31827515 [PubMed]
Recent increases in colorectal cancer (CRC) incidence in adults less than 50 years of age have led to more colonoscopies in this age group. As a result, there may be an increasing number of adults1cm) serrated polyps in younger versus older adults who return for a follow-up colonoscopy.
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In conclusion, colorectal cancer in young adults occurs without obvious risk factors in Burkina Faso. Mortality remains high because of the limited therapeutic arsenal. PMID: 31615647 [PubMed - as supplied by publisher]
Publication date: December 2019Source: Cancer Epidemiology, Volume 63Author(s): Olatunji B. Alese, Renjian Jiang, Katerina M. Zakka, Christina Wu, Walid Shaib, Mehmet Akce, Madhusmita Behera, Bassel F. El-RayesAbstractBackgroundThe incidence of colorectal cancer (CRC) in young adults is increasing. Minority populations with CRC are known to have worse survival outcomes. The aim of this study is to evaluate adults under age 50 years with CRC by race and ethnicity.MethodsData were obtained from all US hospitals that contributed to the National Cancer Database (NCDB) between 2004 and 2013. Univariate and multivariable testing...
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