Assessing the Potential of Liposomes Loaded with Curcumin as a Therapeutic Intervention in Asthma

Publication date: Available online 16 August 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Zhao Yin Ng, Jin-Ying Wong, Jithendra Panneerselvam, Thiagarajan Madheswaran, Pradeep Kumar, Viness Pillay, Alan Hsu, Nicole Hansbro, Mary Bebawy, Peter Wark, Philip Hansbro, Kamal Dua, Dinesh Kumar ChellappanAbstractCurcumin a component of turmeric, which is derived from Curcuma longa is used as a coloring agent and as a dietary spice for centuries. Extensive studies have been done on the anti-inflammatory activity of curcumin along with its molecular mechanism involving different signalling pathways. However, the physicochemical and biological properties such as poor solubility and rapid metabolism of curcumin have led to low bioavailability and hence limits its application. Current therapies for asthma such as bronchodilators and inhaled corticosteroids (ICS) are aimed at controlling disease symptoms and prevent asthma exacerbation. However, this approach requires lifetime therapy and is associated with a constellation of side effects. This creates a clear unmet medical need and there is an urgent demand for new and more-effective treatments. The present study is aimed to formulate liposomes containing curcumin and evaluate for its anti-inflammatory effects on lipopolysaccharide (LPS)-induced inflammation on BCi-NS1.1 cell line. Curcumin and salbutamol liposomes were formulated using lipid hydration method. The prepared liposomes were characterized in terms of particle...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research