Pentavalent phosphorus as a unique phosphorus donor in POCl3 homodimer and POCl3 –H2O heterodimer: matrix isolation infrared spectroscopic and computational studies

Phys. Chem. Chem. Phys., 2018, Advance Article DOI: 10.1039/C8CP03937B, PaperP. K. Sruthi, N. Ramanathan, Shubhra Sarkar, K. Sundararajan Phosphorus, an important element among the pnicogen group, opens up avenues for experimental and computational explorations of its interaction in a variety of compounds. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Phys. Chem. Chem. Phys. latest articles - Category: Chemistry Authors: Source Type: research

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We describe procedures for documenting exposures to monkeypox virus infection in study participants, and outline lessons learned that may be of relevance for studies of other investigational countermeasures in hard to reach, under-resourced populations.
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: Available online 12 November 2018Source: Antiviral ResearchAuthor(s): Yuchen Xia, Martin Schlapschy, Volker Morath, Natalie Roeder, Elisabeth I. Vogt, Daniela Stadler, Xiaoming Cheng, Ulf Dittmer, Kathrin Sutter, Mathias Heikenwalder, Arne Skerra, Ulrike ProtzerAbstractInterferon α (IFNα) so far is the only therapeutic option for chronic hepatitis B virus (HBV) infection that can lead to virus clearance. Unfortunately, its application is limited by side effects and response rates are low. The aim of this study was to generate a novel long-acting IFNα with the help of PASylation technolog...
Source: Antiviral Therapy - Category: Virology Source Type: research
In conclusion, we constructed the H7N9 influenza subunit vaccine candidate HA1-2-FliCΔD2D3, with reduced immunogenicity against FliC and lower adverse events. The improved adjuvant FliCΔD2D3 can potentially help in developing safe and effective universal protein-based influenza vaccines for humans.
Source: Antiviral Therapy - Category: Virology Source Type: research
Publication date: October 2018Source: Current Opinion in Virology, Volume 32Author(s): Francesca Ceccherini-Silberstein, Valeria Cento, Velia Chiara Di Maio, Carlo Federico Perno, Antonio CraxìThe introduction of new multi-genotypic direct acting antivirals (DAA) in clinical practice has revolutionized HCV treatment, permitting the achievement of>95% rates of sustained virological response in many patients. However, virological failures can occur particularly if the treatments are sub optimal and/or with too short duration. Failure is often associated with development of resistance. The wide genetic variability i...
Source: Current Opinion in Virology - Category: Virology Source Type: research
Publication date: October 2018Source: Current Opinion in Virology, Volume 32Author(s): Mayke Leggewie, Esther SchnettlerAntiviral RNA interference (RNAi) in insects is known for some time. Previously, data from the model organism Drosophila was lightly transferred to other insects. However, since more research is performed on other insects, both similarities and important differences among the RNAi pathways of insects are revealed.The piRNA pathway, for example, is suggested to have antiviral functions in mosquitoes, which is unknown for other insects. Moreover, production of viral cDNA from RNA viruses during infection an...
Source: Current Opinion in Virology - Category: Virology Source Type: research
Publication date: January 2019Source: Ticks and Tick-borne Diseases, Volume 10, Issue 1Author(s):
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 13 November 2018Source: Ticks and Tick-borne DiseasesAuthor(s): Amalia Segura, Oscar Rodríguez, Francisco Ruiz-Fons, Pelayo AcevedoAbstractMacroparasites in general, and ectoparasites in particular, have the potential to regulate host population dynamics. In this context, this study addresses the tick parasitism traits of the Mediterranean spur-thighed tortoise (Testudo graeca) in the core area of its distribution range (northwestern Morocco, Maamora). It was discovered that 92.5% of the tortoises were parasitized by ticks in spring, with an infestation intensity and an abundance o...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
This study reports the etiological identification, clinical diagnosis, and the results of the local epidemiological surveillance of the first case of severe fever with thrombocytopenia syndrome virus (SFTSV) infection in 2014 in Hunan Province, China. The infected patient was isolated and closely monitored. The virus is a member of the Bunyaviridae sandfly family and is characterized by real-time PCR, electron microscopy, immunofluorescence, and whole-genome sequencing. We also detected IgG and IgM antibodies against SFTSV among the local human population and domestic animals in a serological surveillance. Prevalence of SF...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 13 November 2018Source: Ticks and Tick-borne DiseasesAuthor(s): M.G. Montes Cortés, J.L. Fernández-García, M.Á. HabelaAbstractTwo haemoparasites, Theileria equi and Babesia caballi, cause equine piroplasmosis (EP), one of the most prevalent tick-borne diseases in horses. The main aim of the present study was to develop and evaluate a multinested PCR (mn-PCR) for simultaneous detection of the equine piroplasmids T. equi and B. caballi, by amplification of five genetic markers (18S rRNA, β-tubulin, cytB, EMA-1 and RAP-1). This novel assay detected a high pre...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
In this study, the presence of Ehrlichia spp. in ticks in Japan was studied by using isolation and molecular detection methods. In total, 1,237 ticks were collected from vegetation in western, central, and eastern parts of Japan. The ticks were tested for detection of ehrlichial DNA with a nested polymerase chain reaction and/or isolation by inoculation of mice with the homogenate. Ehrlichial DNA was detected in 29 of these ticks. The ehrlichial DNAs, groEL and 16S rRNA genes, detected in Ixodes turdus showed a high similarity to those of E. chaffeensis with 94.7% and 99.2% identity, respectively. Ehrlichia sp. HF and Cand...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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