Effect of Celecoxib on Surgical Site Inflammation After Total Knee Arthroplasty: A Randomized Controlled Study

Objective: To evaluate the anti-inflammatory effectiveness of celecoxib and its effect on the rehabilitation of joint function after total knee arthroplasty. Methods: 72 who patients presented between 2016 and 2017 were divided into two groups. The experimental group was given 200 mg celecoxib twice daily with tramadol hydrochloride 50 mg twice daily (as required); the control group was given tramadol hydrochloride 50 mg twice daily for 6 weeks from the first day after total knew arthroplasty. Skin temperature around the knee was measured 1 day before surgery, on postoperative days 1 and 3, and at week 1, 2 and 6. Inflammatory markers (white blood cell count, C-reactive protein, erythrocyte sedimentation rate, and interleukin-6) were measured preoperatively, on postoperative day 3, and at week 1 and 6. Knee Society Score (KSS) was recorded preoperatively and at postoperative weeks 1, 2 and 6. Results: Except for preoperative skin temperature, the recorded skin temperatures of the experimental group were significantly different compared to those of the control group (p = 0.001, 0.024, 0.030, 0.041, 0.047 respectively). Levels of C-reactive protein were significantly different at the first and the sixth week after surgery, differing by 19.3 ± 4.64 mg/L (p
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research