Farnesoid X receptor inhibits proliferation of human colorectal cancer cells via the miR ‑135A1/CCNG2 signaling pathway.

In conclusion, activation of FXR by GW4064 suppresses cell proliferation and causes cell cycle arrest in CRC, and the miR‑135A1/CCNG2 pathway was suggested to be involved in this step. PMID: 30106441 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

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Publication date: Available online 16 September 2019Source: Pathology - Research and PracticeAuthor(s): Ha Yoon Mo, Hyun Ji Son, Eun Ji Choi, Nam Jin Yoo, Chang Hyeok An, Sug Hyung Lee
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Publication date: Available online 16 September 2019Source: Journal of ColoproctologyAuthor(s): Makki H. Fayadh, Salem Awadh Sabih, Hadi Affan Quadri
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
Hyperplastic polyps, once thought to have a benign course, are now part of a larger heterogeneous group known as serrated polyps, which include hyperplastic polyps (HPs), sessile serrated polyps (SSPs), and traditional serrated adenomas (TSAs). The latter group, once known as serrated adenomas, are relatively rare, accounting for less than 5% of all serrated polyps. Thus, it is not surprising that less is known about these lesions than about conventional adenomas or even SSPs. Because these lesions have dysplasia and can progress to colorectal cancer (CRC), more data regarding prevalence and risk factors TSAs are vital.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
ConclusionsPET/CT was useful for early detection of EPCs. The use of PET/CT for the early detection and treatment of EPCs with no symptoms can improve treatment outcomes.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
We examined incidence, mortality and survival over three decades in a large population-based registry study.MethodsThis retrospective study included all cases (n = 4580) of NETs diagnosed from 1986 to 2015 in Queensland, Australia. We examined directly age-standardised incidence and mortality rates. The impact on overall survival according to demographic factors and primary site was modelled using multivariable Cox proportional hazards regression (HR). Cause-specific and relative survival were estimated using the Kaplan-Meier survival function.ResultsAnnual incidence increased from 2.0 in 1986 to 6.3 per 100,...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: 16 September 2019Source: Cancer Cell, Volume 36, Issue 3Author(s): Rene Jackstadt, Sander R. van Hooff, Joshua D. Leach, Xabier Cortes-Lavaud, Jeroen O. Lohuis, Rachel A. Ridgway, Valérie M. Wouters, Jatin Roper, Timothy J. Kendall, Campbell S. Roxburgh, Paul G. Horgan, Colin Nixon, Craig Nourse, Matthias Gunzer, William Clark, Ann Hedley, Omer H. Yilmaz, Mamunur Rashid, Peter Bailey, Andrew V. BiankinSummaryThe metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NOTCH1 signaling in the murine intestinal epithelium le...
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Publication date: 16 September 2019Source: Cancer Cell, Volume 36, Issue 3Author(s): Jürgen RulandIn this issue of Cancer Cell, Jackstadt et al. report that pathological Notch signaling in colorectal cancer (CRC) cells can initiate a neutrophil-dependent, TGF-β-mediated cascade that leads to metastatic disease. Inhibition of this pathway with clinically relevant compounds blocks metastatic spread in a developed murine model of CRC.
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research
Authors: Tong J, Shen Y, Chen X, Wang R, Hu Y, Zhang X, Zhang Z, Han L Abstract Colorectal cancer (CRC), a commonly occurring malignant tumor in the gastrointestinal tract, is the third leading cause of cancer‑related deaths worldwide. FK506‑binding proteins (FKBPs) comprise an immunophilin family that are involved in the carcinogenesis, progression and chemoresistance of cancers, including CRC. FKBP3 (also known as FKBP25) is a nuclear protein that is a member of the FKBP family and is correlated with the activity of histone deacetylase 2 (HDAC2). However, the role of FKBP3 and HDAC2 in oxaliplatin resistance ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Authors: Gu J, Wang L, Li T, Tang S, Wang Y, Zhang W, Jiang X Abstract Oxaliplatin (OXA) is routinely used as the first‑line treatment for colorectal cancer (CRC). The addition of OXA to chemotherapy has significantly improved the prognosis of patients with CRC; however, some cases are resistant to OXA. The present study explored the influence of organic cation transporter 3 (OCT3) expression on the effects of OXA on CRC cell viability, and investigated the direct effects of OCT3 on viability, invasion and migration of CRC cells using MTT assay, wound healing assay, reverse transcription‑quantitative polymerase...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
SMC1 promotes proliferation and inhibits apoptosis through the NF‑κB signaling pathway in colorectal cancer. Oncol Rep. 2019 Aug 08;: Authors: Li J, He J, Wang Y, Shu Y, Zhou J Abstract Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer‑associated mortality globally. Increasing evidence has indicated that structural maintenance of chromosomes 1 (SMC1) may serve an important role in solid tumors as a tumor enhancer. In the present study, it was identified via reverse transcription‑quantitative PCR and western blot analyses that expression of SMC1 was s...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
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