Lymphatic Transport and Lymph Node Location of Microspheres Subcutaneously Injected in the Vicinity of Tumors in a Rabbit Model of Breast Cancer

Conclusions1  μm MS arrived numerously into the areas low-invaded and non-invaded by the tumoral cells of the pathologic LN, but they were very rare in the fully invaded regions. Compared to the 100 nm nanospheres, the 1 μm were better retained (20 times) into the sentinel LN, showing the advantage of micro metric particles for lymph-targeted chemotherapy when injected before complete invasion by metastases.
Source: Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research