' An Inconvenient Truth': Add Bev or Chemo to TKIs in Lung Cancer'An Inconvenient Truth': Add Bev or Chemo to TKIs in Lung Cancer

What agents can you combine with a TKI to improve progression-free survival inEGFR-mutant lung cancer? Dr Mark Kris discusses recent data from ASCO on this topic.Medscape Oncology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

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Publication date: Available online 21 September 2018Source: The Lancet HIVAuthor(s): Nancy A Hessol, Hannah Whittemore, Eric Vittinghoff, Ling C Hsu, Danning Ma, Susan Scheer, Sandra K SchwarczSummaryBackgroundCancer survivors are at increased risk for subsequent primary cancers. People living with HIV are at increased risk for AIDS-defining and non-AIDS-defining cancers, but little is known about their risk of first versus second primary cancers. We identified first and second primary cancers that occurred in above population expected numbers among people diagnosed with HIV in San Francisco, and compared first and second ...
Source: The Lancet HIV - Category: Infectious Diseases Source Type: research
Publication date: Available online 19 September 2018Source: Microbial PathogenesisAuthor(s): Govindan Rajivgandhi, Thillaichidambaram Muneeswaran, Muthuchamy Maruthupandy, Kandasamy Saravanan, Vilwanathan Ravikumar, Natesan ManoharanAbstractThe current study aimed to identify bioactive compound from marine endophytic actinomycetes isolated from Gulf of Mannar, southeast coast of India. Among the isolated actinomycetes, strain GRG 4 exhibited excellent ability to inhibit colistin resistant (CR) Pseudomonas aeruginosa and Klebsiella pneumonia, which emerging threat to the world. The strain was identified as Streptomyces coer...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
ConclusionThis is the first study demonstrating efficacy of DLA and mechanistic differences of DLAe vs. AS, against NSCLC cells. Compared to AS, DLA possesses qualities of a novel therapeutic for patients with NSCLC.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
ConclusionsNeither patient nor physician race was significantly associated with risk estimation or surgical recommendations. These findings do not provide an explanation for documented racial disparities in lung cancer therapy. Further investigation is needed to identify the mechanism underlying these disparities.Visual Abstract
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionsIn a large database study, the addition of radiotherapy to adjuvant chemotherapy after resection of N2 NSCLC was not associated with improved survival. Until more definitive data are available, consideration should be given to treating patients with N2 disease detected at resection with adjuvant chemotherapy only.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: October 2018Source: The Annals of Thoracic Surgery, Volume 106, Issue 4Author(s): Stephanie Tuminello, Andrea Wolf, Emanuela Taioli, Raja Flores
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: October 2018Source: The Annals of Thoracic Surgery, Volume 106, Issue 4Author(s): Niravkumar K. Sangani, Santosh Mathew NaliathA 44-year-old man presented with spontaneous massive hemothorax. Computed tomographic scan revealed thickened and nodular pleura with no evidence of lung tumor. The patient underwent right open total pleurectomy. Histopathologic and immunohistochemical studies of the pleura confirmed poorly differentiated sarcomatoid squamous cell carcinoma of the lung with metastasis to the pleura. The carcinoma was psuedomesothelimatous type because of its presentation as diffuse pleural thicken...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: October 2018Source: The Annals of Thoracic Surgery, Volume 106, Issue 4Author(s): Seth B. Krantz, John A. Howington, Douglas E. Wood, Ki Wan Kim, Andrzej S. Kosinski, Morgan L. Cox, Sunghee Kim, Michael S. Mulligan, Farhood FarjahBackgroundPrior studies suggest underutilization of invasive mediastinal staging for lung cancer. We hypothesized that The Society of Thoracic Surgeons General Thoracic Surgery Database (STS-GTSD) participants would have higher rates of invasive staging compared with previous reports.MethodsWe conducted a retrospective cohort study (2012 to 2016) of lung cancer patients stag...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
This study investigated the frequency of and risk factors for preoperative carotid artery stenosis to determine whether CAS with ultrasonography contributes to preventing postoperative stroke or cardiovascular comorbidities in lung cancer patients.MethodsThis retrospective study included 1,676 consecutive lung cancer patients who underwent surgical resection.ResultsOf the 1,342 patients who underwent CAS, 173 (12.9%) had carotid artery stenosis. Significant associations with carotid artery stenosis were found for older patients (p
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionsInduction chemotherapy with concurrent radiotherapy (50 Gy), followed by resection, was a feasible and promising treatment option for resectable c-stage IIIA-N2 NSCLC.Visual Abstract
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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