Thermodynamics and kinetics of joint action of antiviral agent tilorone and DMSO on model lipid membranes

Publication date: Available online 15 August 2018Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): N.A. Kasian, O.V. Vashchenko, L.V. Budianska, R.Ye. Brodskii, L.N. LisetskiAbstractIndividual and joint action of two water-soluble drugs, DMSO and tilorone, on model l-α-dipalmitoylphosphatidylcholine (DPPC) membranes were studied in equilibrium and kinetic regimes by differential scanning calorimetry (DSC). For equilibrium experiments, the drugs were introduced during preparation of the model membrane. In kinetic studies, one of the drugs was added to the DPPC membrane already containing the other drug, and the effects of drug-membrane interactions were monitored in real-time regime. It was found that tilorone and DMSO had opposite effects on the membrane melting temperature, which were non-additive under joint introduction of these drugs. Analysis of kinetics of DSC profiles under drugs introduction allowed us to discriminate two processes in drug-membrane interactions with different characteristic times, i.e., drug sorption onto the membrane (minutes) and drug diffusion through stacks of lipid bilayers (hours). It was established that 0.1 mol% DMSO effectively enhanced membrane penetration for tilorone with the rate of tilorone diffusion being dependent upon the scheme of drugs administration. A model was proposed describing how sorption of a dopant onto lipid membrane could affect the membrane permeability for other dopants. Conditions were determ...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research

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ontenegro H PMID: 31002013 [PubMed - in process]
Source: Acta Odontologica Scandinavica - Category: Dentistry Authors: Tags: Acta Odontol Scand Source Type: research
PMID: 31002012 [PubMed - in process]
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Publication date: 1 June 2019Source: Materials Chemistry and Physics, Volume 231Author(s): Bharat Baruah, Latanya Downer, David AgyemanAbstractThis work demonstrates immobilization of ZnO nanorods (ZnO-NRs) on the cotton fabric (CF) and subsequent modification of the ZnO-NRs with gold nanoparticles (AuNPs). AuNPs was ex-situ synthesized using citrate method followed by deposition of the same on ZnO-NRs immobilized on CF thereby generating CF@ZnO-NRs and CF@ZnO-NRs-AuNPs composites materials. The surface morphology of these composite materials probed by scanning electron microscopy (SEM), energy dispersive X-ray analysis (E...
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Source: Food Hydrocolloids - Category: Food Science Source Type: research
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Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
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Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
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Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study, we have experimented for the lactic acid production using Lactobacillus delbrueckii MTCC 911 with Prosopis juliflora as a substrate for fermentation. As a result, 38.23 g/L of lactic acid was produced. Modified ring-opening polymerization with direct polycondensation method was followed to convert lactic acid into polylactic acid, and membrane prepared with 0.25 mm thickness having PLA/chitosan 60/40 composition shows better results with a tensile strength of 17.809 MPa and an elongation at break of 300.11%. The oxygen transmission rate results show low permeability of 1614.21 (cm3/(m2·...
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Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
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