Thermodynamics and kinetics of joint action of antiviral agent tilorone and DMSO on model lipid membranes

Publication date: Available online 15 August 2018Source: Biochimica et Biophysica Acta (BBA) - BiomembranesAuthor(s): N.A. Kasian, O.V. Vashchenko, L.V. Budianska, R.Ye. Brodskii, L.N. LisetskiAbstractIndividual and joint action of two water-soluble drugs, DMSO and tilorone, on model l-α-dipalmitoylphosphatidylcholine (DPPC) membranes were studied in equilibrium and kinetic regimes by differential scanning calorimetry (DSC). For equilibrium experiments, the drugs were introduced during preparation of the model membrane. In kinetic studies, one of the drugs was added to the DPPC membrane already containing the other drug, and the effects of drug-membrane interactions were monitored in real-time regime. It was found that tilorone and DMSO had opposite effects on the membrane melting temperature, which were non-additive under joint introduction of these drugs. Analysis of kinetics of DSC profiles under drugs introduction allowed us to discriminate two processes in drug-membrane interactions with different characteristic times, i.e., drug sorption onto the membrane (minutes) and drug diffusion through stacks of lipid bilayers (hours). It was established that 0.1 mol% DMSO effectively enhanced membrane penetration for tilorone with the rate of tilorone diffusion being dependent upon the scheme of drugs administration. A model was proposed describing how sorption of a dopant onto lipid membrane could affect the membrane permeability for other dopants. Conditions were determ...
Source: Biochimica et Biophysica Acta (BBA) Biomembranes - Category: Biochemistry Source Type: research

Related Links:

Publication date: Available online 16 November 2018Source: Journal of Environmental SciencesAuthor(s): Lin Chen, Chengyi Wang, Shanshan Liu, Liang ZhuAbstractThe adsorption and desorption behavior of Cr(VI) in membrane capacitive deionization (MCDI) was investigated systematically in the presence of bovine serum albumin (BSA) and KCl with different concentrations, respectively. Results revealed that Cr(VI) absorption was enhanced and the adsorption amount for Cr(VI) increased from 155.7 to 190.8 mg/g when KCl concentration increased from 100 to 200 mg/L in the adsorption process, which was attributed to the stronger dr...
Source: Journal of Environmental Sciences - Category: Environmental Health Source Type: research
Publication date: 2018Source: European Journal of Radiology Open, Volume 5Author(s): Lokesh Rana, Dinesh Sood, Raman Chauhan, Roshni Shukla, Pooja Gurnal, Himanshu Nautiyal, Manvendra TomarAbstractBackground and purposeNeonatal hypoxic-ischemic encephalopathy causes hypoxic brain injury. Due to differences in brain maturity at time of insult, severity of hypotension and duration of insult, there are four distinct patterns of brain injury. Magnetic resonance imaging is the most sensitive modality for evaluating these patterns of brain injury. Additional role of Diffusion weighted imaging and ADC values can be useful in the ...
Source: European Journal of Radiology Open - Category: Radiology Source Type: research
This study aimed to evaluate the intra- and interobserver agreement for fracture classifications of the glenoid, using either plain radiographs, computed tomography (CT) scans. The study was retrospective, using images with a variety of fracture types. Six observers classified the fracture patterns. Classifications of Ideberg, OTAAO, Mayo and Euler/Ruedi were used. Agreement was determined using kappa coefficients. Currently used glenoid fracture classification systems have a fair to moderate intraobserver reliability. Combining plain radiographs and CT scans led to a better observer agreement. For interoberserver reliabil...
Source: Acta Orthopaedica Belgica - Category: Orthopaedics Tags: Acta Orthop Belg Source Type: research
For a well-established product like the hearing aid, the market is a dynamic one with incredible growth opportunities. “There’s only about a 20% penetration in the space,” reported Dave Olson, CEO of Elevated Technologies/Elevated Hearing. “A lot of people can’t afford hearing aids or think wearing them would be unappealing. But there are a lot of forces at work to make them more appealing and affordable.” The market for these devices is growing about 8%, according to market research firm ResearchAndMarkets, whose es...
Source: MDDI - Category: Medical Devices Authors: Tags: MD & M Minneapolis Design Source Type: news
Publication date: Available online 16 November 2018Source: Journal of Cranio-Maxillofacial SurgeryAuthor(s): Diana Cassi, Giuditta Battistoni, Marisabel Magnifico, Chiara Di Blasio, Giuseppe Pedrazzi, Alberto Di BlasioSummaryPurposeTo quantify the surface facial asymmetry in a group of young patients with hemifacial microsomia (HFM) and to investigate differences with a homogeneous sample of healthy subjects, using a novel stereophotogrammetric method.Materials and MethodsTwelve patients (mean age 13.1 ± 3.1 years) with different degrees of HFM and 15 healthy controls (mean age 12.2 ± 3.5 years) were imaged w...
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
ConclusionThe new concept was evaluated and showed a similar behavior to the intact model, and better behavior than the Biomet. The innovative concept proves that it is possible to avoid screws for a TMJ fixation and improve the TMJ alloplastic behavior.
Source: Journal of Cranio Maxillofacial Surgery - Category: ENT & OMF Source Type: research
We describe two LIFT cases referred from other institutions after unsuccessful conservative treatment of OLT. They presented with pain, swelling and tenderness over the anterolateral aspect of the right ankle. We recognized the LIFT lesion on the magnetic resonance imaging scans in patient 2, while in patient 1 the orientation of the fragment was recognized upon direct visualization during operative treatment. Both patients underwent arthroscopic procedure. Due to articular cartilage damage and insufficiency of the adjacent bone of the fragment, both patients were treated with excision fol-lowed by microfracture. Treatment...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
Authors: Mišič J, Popović P, Hribernik M, Starc A, Dahmane R Abstract In the liver, there are many vascular variants, which are important in liver surgery, the presence of accessory right hepatic veins (aRHVs) in particular. Th eir frequency, number and diameter vary considerably. Detailed imaging diagnostics with computed tomography (CT) should be undertaken before surgery. Th e aim of our study was to examine the characteristics of aRHVs and their demographic correlations. Th e study included data on 188 patients that underwent CT examination of the abdomen with contrast media, 103 men (54.8%) men and 85...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
Authors: Ostojić J, Brčić L, Hrabač P, Seiwerth S Abstract Lung cancer as the major cause of cancer mortality worldwide includes several histologic subtypes evolving from numerous genetic and epigenetic changes emerging in alveolar, bronchiolar and bronchial epithelium. The majority of cases are diagnosed in advanced stage (i.e. stages IIIB and IV), often with scanty amount of tissue in transbronchial biopsies or cytology specimens. The aim of the present study was to investigate the expression of the scaffolding protein neural precursor cell expressed, developmentally downregulated 9 (NEDD9) in small biopsies ...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
This study provides evidence that CAS is a valid and effective treatment option regardless of whether patients exhibited ROAF or not. Patients without ROAF were significantly more likely to have improved mid-term functional outcomes compared to those with ROAF. In the group without ROAF admission, CRP may play a role in predicting subsequent functional outcomes, whereas admission Barthel Index was a predictor of outcome in the ROAF group. PMID: 30433861 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
More News: Biochemistry | PET Scan | Study