Synthesis and biological activities of carbonyl cobalt CORMs with selectively inhibiting cyclooxygenase-2

Publication date: Available online 15 August 2018Source: Journal of Organometallic ChemistryAuthor(s): Jili Li, Jinlong Zhang, Qiuping Zhang, Zhongjie Bai, Quanyi Zhao, Zhen Wang, Yonglin Chen, Bin LiuAbstractIn this paper, three kinds of hybrid carbonyl cobalt CO-releasing molecules (CORMs), RCOOCH2C2H[Co2(CO)6] (R = NSAIDs-COOH, 1–11; R = celecoxib derivative-COOH, 15), RSO2(R’) CH2C2H[Co2(CO)6] (R = celecoxib, 12; R = nimesulide, 13) and ROCH2C2H[Co2(CO)6] (R = ferulic acid etheyl ester, 14), were synthesized and characterized by IR, NMR and HRMS. The crystal structures of complexes 9, 11, 14 and 16 were determined by single-crystal X-ray diffraction. Meanwhile, the anti-tumor activity, protection on oxidative damage of H9c2 cells, anti-hypertension and myocardial protective effects were evaluated. The results showed only a part of the complexes had anticancer activity for the five cell lines compared with 5-FU. Among them, complexes 12 and 13 which modified by selective COX-2 inhibitors displayed strong antiproliferative activity and selectivity to MCF-7 cell and HT-29 cell lines, and their IC50 values were 33.6–55.8 μM; but compared with cis-platin (DDP), they showed slightly lower activities. The complex inhibited the expression of COX-2 in HT-29 cells and MCF-7 cells, and complex 12 had stronger inhibitory effects than the others, which was accordance with its stronger activity against cell proliferation. Secondly, the...
Source: Journal of Organometallic Chemistry - Category: Chemistry Source Type: research

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