What’s in a (Sub)strain?

Publication date: 14 August 2018Source: Stem Cell Reports, Volume 11, Issue 2Author(s): Jill M. Goldstein, Amy J. WagersC57BL/6J and C57BL/6N inbred mice are widely, and often interchangeably, used for stem cell research; yet, these substrains harbor discrete genetic differences that can cause phenotypic disparities. In this issue of Stem Cell Reports, Morales-Hernández et al. identify one particular difference—disruption of Nicotinamide Nucleotide Transhydrogenase (Nnt)—that increases reactive oxygen exposure and impairs hematopoietic progenitor cell function in C57BL/6J, as compared to C57BL/6N, mice.
Source: Stem Cell Reports - Category: Stem Cells Source Type: research