Is Severe and Long-lasting Linezolid-induced Optic Neuropathy Reversible?

Is Severe and Long-lasting Linezolid-induced Optic Neuropathy Reversible? Intern Med. 2018 Aug 10;: Authors: Lee S, Kang BH, Ryu WY, Um SJ, Roh MS, Son C Abstract Linezolid is a useful drug for treating drug-resistant tuberculosis. However, the associated toxicities, especially optic neuritis, are a major obstacle for its long-term use. We recently experienced a case of severe optic and peripheral neuropathy during the treatment of multidrug-resistant tuberculosis. The treatment continued for 12 months despite severe optic and peripheral neuropathy. At eight months after the discontinuation of the drug, the optic neuropathy recovered, but the peripheral neuropathy did not. Considering the grave prognosis of drug-resistant tuberculosis, the continuation of linezolid despite neurotoxicity under close observation may be a suitable option. PMID: 30101940 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research