Therapeutics for Adult Nail Psoriasis and Nail Lichen Planus Therapeutics for Adult Nail Psoriasis and Nail Lichen Planus

This article presents an approach for selecting current topical and systemic therapies, including new biologics.American Journal of Clinical Dermatology
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

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CONCLUSION: K17 is potentially expressed in certain inflammatory skin diseases, including psoriasis and lichen planus. Besides, it is not always a marker of hyperproliferation of keratinocytes in skin diseases.PMID:34552343 | PMC:PMC8450673 | DOI:10.2147/CCID.S322226
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Authors: Source Type: research
Acta Derm Venereol. 2021 Sep 7. doi: 10.2340/00015555-3917. Online ahead of print.ABSTRACTNail dermoscopy (onychoscopy) is a valuable diagnostic tool for evaluating diseases in the nail apparatus. It is non-invasive, allowing clinicians to prioritize particular nails for biopsy. Thus, it can improve diagnostic accuracy and expedite treatment. Evaluating inflammatory nail disorders using onychoscopy is a relatively new approach to clinical assessment and has the potential to augment clinical care. This review highlights key dermoscopic features of major inflammatory nail disorders, including trachyonychia, nail psoriasis, n...
Source: Acta Derm Venereol A... - Category: Dermatology Authors: Source Type: research
J Mol Med (Berl). 2021 Aug 9. doi: 10.1007/s00109-021-02105-y. Online ahead of print.ABSTRACTAdenosine triphosphate-binding cassette subfamily B member 1 (ABCB1), also known as permeability glycoprotein, multidrug-resistant protein 1, or cluster of differentiation 243 (CD243), is a crucial protein for purging foreign substances from cells. The functions of ABCB1 have been investigated extensively for their roles in cancer, stem cells, and drug resistance. Abundant pharmacogenetic studies have been conducted on ABCB1 and its association with treatment responsiveness to various agents, particularly chemotherapeutic and immun...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Exp Ther Med. 2021 Sep;22(3):987. doi: 10.3892/etm.2021.10419. Epub 2021 Jul 13.ABSTRACTOral lichen planus (OLP) is a complex chronic inflammatory disorder in which autocytotoxic CD8+ T cells, locally present in the affected tissue, induce basal keratinocyte apoptosis, through the release of several cytokines, such as interleukin-6 (IL-6). IL-6 is a proinflammatory cytokine that is related to alterations in lipid metabolism in psoriasis patients. Impaired lipid metabolism together with high serum levels of triglycerides have been found in association with OLP. However, the correlation between serum levels of IL-6 and dysli...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Authors: Source Type: research
CONCLUSION: Identifying the etiology facilitates early treatment and hence reduces the infectivity and transmission of disease and also the disease complications like phimosis. In addition, multiple infectious etiologies should always be kept in mind while evaluating STDs.PMID:34322423 | PMC:PMC8284224 | DOI:10.4103/jfmpc.jfmpc_2467_20
Source: Primary Care - Category: Primary Care Authors: Source Type: research
DISCUSSION: The study design is based on experience from studies on apremilast in other inflammatory skin diseases using equivalent apremilast doses for approved indications. The trial may provide evidence for the use of apremilast in women with this burdensome genital dermatosis.TRIAL REGISTRATION: NCT0365666 . Registered on 4 September 2018.PMID:34284808 | PMC:PMC8290211 | DOI:10.1186/s13063-021-05428-w
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
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