Testing the association of serum uric acid levels with behavioral and clinical characteristics in subjects with major affective disorders: A cross-sectional study.

In recent years, several observational studies have investigated uric acid levels among individuals with major affective disorders (Albert et al., 2015; Bartoli et al., 2017b; Black et al., 2018; Peng et al., 2016). Uric acid is a C5H4N4O3 heterocyclic compound deriving from the purinergic metabolism of both adenosine and guanosine (Maiuolo et al., 2016). It has been hypothesized that uric acid might be a marker of dysfunctions in adenosine transmission (Cheffer et al., 2017; Lindberg et al., 2015; Ortiz et al., 2015) and antioxidant system (Bowman et al., 2010; Jim énez-Fernández et al., 2015), in different mental disorders.

Source: Psychiatry Research - August 14, 2018 Category: Psychiatry Authors: Francesco Bartoli, Cristina Crocamo, Mattia Bava, Gloria Castagna, Carmen Di Brita, Ilaria Riboldi, Giulia Trotta, Enrica Verrengia, Massimo Clerici, Giuseppe Carr à Source Type: research