New classification of tauopathies.

New classification of tauopathies.
Rev Neurol (Paris). 2018 Aug 08;:
Authors: Höglinger GU, Respondek G, Kovacs GG
Abstract
Tauopathies are a group of neurodegenerative diseases characterized by pathological intracellular deposits of the protein tau. Isoform composition, morphology and anatomical distribution of cellular tau-immunoreactivities are defining distinct tauopathies as molecular pathological disease entities. The clinical spectrum of tauopathies includes syndromes with primary motor symptoms and with primary cognitive dysfunction. The traditional syndrome-based classification is currently being complemented by a molecular-pathological classification. While the syndrome-based classification is helpful to select symptomatic therapies, and to generate clinical working hypotheses about underlying etiologies, the molecular-pathological classification is most important for the development and application of molecularly tailored disease-modifying therapies.
PMID: 30098799 [PubMed - as supplied by publisher]

Source: Revue Neurologique - August 14, 2018 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research