Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling [Immunology and Inflammation]

The adaptor molecule stimulator of IFN genes (STING) is central to production of type I IFNs in response to infection with DNA viruses and to presence of host DNA in the cytosol. Excessive release of type I IFNs through STING-dependent mechanisms has emerged as a central driver of several interferonopathies,...

Source: Proceedings of the National Academy of Sciences - August 14, 2018 Category: Science Authors: Anne Louise Hansen, Gregory J. Buchan, Michael Ruhl, Koȷiro Mukai, Sonia R. Salvatore, Emari Ogawa, Sidsel D. Andersen, Marie B. Iversen, Anne L. Thielke, Camilla Gunderstofte, Mona Motwani, Charlotte T. Moller, Andreas S. Jakobsen, Katherine A. Fi Tags: PNAS Plus Source Type: research