IJERPH, Vol. 15, Pages 1747: Breast Cancer and Its Relationship with the Microbiota

IJERPH, Vol. 15, Pages 1747: Breast Cancer and Its Relationship with the Microbiota International Journal of Environmental Research and Public Health doi: 10.3390/ijerph15081747 Authors: Mariana F. Fernández Iris Reina-Pérez Juan Manuel Astorga Andrea Rodríguez-Carrillo Julio Plaza-Díaz Luis Fontana The microorganisms that live symbiotically in human beings are increasingly recognized as important players in health and disease. The largest collection of these microorganisms is found in the gastrointestinal tract. Microbial composition reflects both genetic and lifestyle variables of the host. This microbiota is in a dynamic balance with the host, exerting local and distant effects. Microbial perturbation (dysbiosis) could contribute to the risk of developing health problems. Various bacterial genes capable of producing estrogen-metabolizing enzymes have been identified. Accordingly, gut microbiota is capable of modulating estrogen serum levels. Conversely, estrogen-like compounds may promote the proliferation of certain species of bacteria. Therefore, a crosstalk between microbiota and both endogenous hormones and estrogen-like compounds might synergize to provide protection from disease but also to increase the risk of developing hormone-related diseases. Recent research suggests that the microbiota of women with breast cancer differs from that of healthy women, indicating that certain bacteria may be associated with cancer development and with differen...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Review Source Type: research