Loss of nuclear localized Parathyroid Hormone-related Protein in primary breast cancer predicts poor clinical outcome and correlates with suppressed Stat5 signaling.

CONCLUSIONS: This study overturns the prevailing view that PTHrP is upregulated in primary breast cancers and identifies a direct prolactin-Stat5-PTHrP axis that is progressively lost in more aggressive tumors. PMID: 30097435 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30097435?dopt=Abstract

Source: Clinical Cancer Research - August 10, 2018 Category: Cancer & Oncology Authors: Tran TH, Utama FE, Sato T, Peck AR, Langenheim JF, Udhane SS, Sun Y, Liu C, Girondo MA, Kovatich AJ, Hooke JA, Shriver CD, Hu H, Palazzo J, Bibbo M, Auer PL, Flister MJ, Hyslop TM, Mitchell EP, Chervoneva I, Rui H Tags: Clin Cancer Res Source Type: research