Clinical trial suggests new direction for heavy-smoking head and neck cancer patients

(University of Colorado Anschutz Medical Campus) Phase I results of olaparib with cetuximab and radiation led to 72 percent 2-year survival in 16 patients on trial, compared with an expected 2-year survival rate of about 55 percent for standard-of-care treatment.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Abbas K, Abbasi NY, Ali A, Khan SA, Manzoor S, Khalil A, Khalil U, Khan DM, Hussain Z, Altaf M Abstract The medical data are often filed for each patient in clinical studies in order to inform decision-making. Usually, medical data are generally skewed to the right, and skewed distributions can be the appropriate candidates in making inferences using Bayesian framework. Furthermore, the Bayesian estimators of skewed distribution can be used to tackle the problem of decision-making in medicine and health management under uncertainty. For medical diagnosis, physician can use the Bayesian estimators to quanti...
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
The objective of the present study was to provide clinicians with the necessary diagnostic tools, based on the current state of clinical, imaging and pathologic knowledge, and to detail treatment options.
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - Category: ENT & OMF Source Type: research
Authors: Zhang M, Deng W, Gong H, Li C, Wang Y, Liu X, Tao L, Zhou L Abstract Laryngeal squamous cell carcinoma (LSCC) is one of the most prevalent types of head and neck malignancies. Advanced LSCC has failed to demonstrate a satisfactory prognosis, despite the progresses in the diagnosis and treatment, and the optimal treatment modality continues to be debated. To evaluate the clinical utility and survival outcomes of adjuvant chemoradiotherapy (CRT) for patients with resected advanced LSCC, a retrospective analysis of 232 patients with LSCC who had undergone total laryngectomy and neck dissection between 2005 an...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Conclusion Transcutaneous electrical nerve stimulation improves pain in HNC patients receiving radiation but not function or pain with function relative to placebo or no TENS. Implications for Practice Transcutaneous electrical nerve stimulation may be a viable tool for radiation-induced HNC pain to complement pharmacologic approaches. This nonpharmacologic intervention could decrease the debilitating effects of radiation and analgesics, and improve quality of life. Clinical trials should examine the effects and safety of repeated, daily TENS in HNC patients receiving radiation.
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES Source Type: research
Conclusions MDSC are major players in the immunosuppressive scenario in cancer, thanks to their phenotype heterogeneity and critical interaction with several innate immune cells, thus representing a crucial target in oncology. Here we reviewed the interactions of MDSCs with NK cells. The contribution of key cytokines, chemokines and mediators active in this process have been discussed. We also described the contribution of MDSC on angiogenesis directly or indirectly through interactions with NK and immunosuppressive activities. A parallel of the cancer associated to the decidual counterpart of these cells is discussed, a...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewThis decade has witnessed increasing interest in the potential role of the oral microbiome in head and neck cancers, particularly oral squamous cell carcinoma (OSCC). Most studies have focused on the bacterial component of the microbiome (bacteriome), but the fungal component (mycobiome) is also receiving attention. In this review, we provide an overview of mechanisms by which the microbiome can contribute to oral carcinogenesis, and summarize results from clinical studies, especially focusing on those reporting functional microbiome analysis. Synthesizing and illustrating the evidence, we also sug...
Source: Current Oral Health Reports - Category: Dentistry Source Type: research
Oral rinse containing doxepin or the combination of diphenhydramine, lidocaine, and antacid may help reduce oral mucositis-related pain in head and neck cancer patients.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news
Conditions:   Head and Neck Cancer;   Radiotherapy Side Effect Intervention:   Other: Electronic Patient-Reported Outcome Sponsors:   Rigshospitalet, Denmark;   Danish Comprehensive Cancer Center;   Danish Cancer Society;   University of Copenhagen;   Danish Head and Neck Cancer Group;   Herlev Hospital;   Zealand University Hospital;   Odense University Hospital;   Aalborg Universitetshospital;   A arhus University ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions In the span of a very short time—less than a decade—robotic head and neck surgery has transformed the management of the head and neck cancer, and it seems clear that the future of treatment for these cancers lies in a multimodal approach in which TORS is likely to play an important role. Nevertheless, it is important to keep in mind that the current indications for TORS are limited and long-term data on the safety and oncological outcomes are needed to better understand the true role of TORS in treatment of head and neck cancer. Nonetheless, the emergence of ever more advanced robotic instruments i...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: CDKN2A and CDKN2B expression analysis can be used as the prognostic marker for the oral cancer patients. The present method of data analysis helps overcome the limitations and complications of high throughput techniques and thereby increases the opportunity of employing molecular markers in routine clinical management of OSCC.
Source: Journal of Oral and Maxillofacial Pathology - Category: ENT & OMF Authors: Source Type: research
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