Clinical trial suggests new direction for heavy-smoking head and neck cancer patients

(University of Colorado Anschutz Medical Campus) Phase I results of olaparib with cetuximab and radiation led to 72 percent 2-year survival in 16 patients on trial, compared with an expected 2-year survival rate of about 55 percent for standard-of-care treatment.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Conclusions18F-FDG PET/CT reclassification was higher than 10% in almost all categories studied (cTNM, tumor extension and nodal disease) and detects more metastases and synchronous tumors than conventional studies, which has an impact on the therapeutic patient management and RT planning.ResumenObjetivosInvestigar el uso de la 18F-FDG(flúor-18 fluorodesoxiglucosa) PET/TC en la estadificación del cáncer de cabeza y cuello (CCC) y su repercusión en la decisión terapéutica y planificación de tratamiento radioterápico.Material y métodosSe incluyen 100 pacientes co...
Source: Revista Espanola de Medicina Nuclear e Imagen Molecular - Category: Nuclear Medicine Source Type: research
Publication date: February 2019Source: Oral and Maxillofacial Surgery Clinics of North America, Volume 31, Issue 1Author(s): Simran K. Sindhu, Julie E. Bauman
Source: Oral and Maxillofacial Surgery Clinics of North America - Category: ENT & OMF Source Type: research
Publication date: February 2019Source: Oral and Maxillofacial Surgery Clinics of North America, Volume 31, Issue 1Author(s): Felix Sim, Rom Leidner, Richard Bryan Bell
Source: Oral and Maxillofacial Surgery Clinics of North America - Category: ENT & OMF Source Type: research
Publication date: February 2019Source: Oral and Maxillofacial Surgery Clinics of North America, Volume 31, Issue 1Author(s): Zvonimir L. Milas, Thomas D. Shellenberger
Source: Oral and Maxillofacial Surgery Clinics of North America - Category: ENT & OMF Source Type: research
Publication date: Available online 15 November 2018Source: The LancetAuthor(s): Hisham Mehanna, Max Robinson, Andrew Hartley, Anthony Kong, Bernadette Foran, Tessa Fulton-Lieuw, Matthew Dalby, Pankaj Mistry, Mehmet Sen, Lorcan O'Toole, Hoda Al Booz, Karen Dyker, Rafael Moleron, Stephen Whitaker, Sinead Brennan, Audrey Cook, Matthew Griffin, Eleanor Aynsley, Martin Rolles, Emma De WintonSummaryBackgroundThe incidence of human papillomavirus (HPV)-positive oropharyngeal cancer, a disease affecting younger patients, is rapidly increasing. Cetuximab, an epidermal growth factor receptor inhibitor, has been proposed for treatmen...
Source: The Lancet - Category: General Medicine Source Type: research
ConclusionIn this large cohort of patients with sinonasal ACC with extended follow ‐up, long‐term survival is better than reported in prior literature. Future research should target patients with adverse risk factors.
Source: Head and Neck - Category: ENT & OMF Authors: Tags: ORIGINAL ARTICLE Source Type: research
We present a prospective large series (n  = 47) of head and neck Ewing's sarcomas (HNES) homogeneously treated by the Euro‐Ewing 99 trial (EE99) from 1999 to 2014 in France. All our findings plead for a multidisciplinary approach of HNES in specialized centers from the diagnosis to maximize for these young patients the chance of cure w ith a minimum of sequelae. We highlight that margin interpretation is crucial to discuss postoperative radiotherapy indication and should be questioned by a multidisciplinary team beyond the only surgeon and pathologist opinion. AbstractBackground, MethodsTo describe the characte...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Publication date: Available online 28 October 2018Source: Seminars in Ultrasound, CT and MRIAuthor(s): John A. Coburn, Edwarda Golden, Justin Brucker, Tabassum A. KennedyNontraumatic vascular emergencies of the head and neck are uncommon, but can occur in patients with central venous catheters, head and neck infections, and in patients with head and neck cancer. Recognizing the imaging findings of vascular complications in these patient populations is critically important to ensure expeditious treatment to avoid significant morbidity and mortality.
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
This study was performed retrospectively on 30 cases diagnosed with OSCC through FISH technique. Molecular cytogenetic techniques, using fluorescence in situ hybridization with chromosome-specific DNA probes, facilitate the confirmation of presumed chromosomal aberrations with high sensitivity and specificity.ResultsOut of 30 cases 29 represent molecular alteration. About 70 % of cases presented chromosome 17 polysomy and only 20% of cases had chromosome 17 monosomy. 58% of samples revealed p53 gene amplification and 37% of them p53 deletion.DiscussionHigh frequency of correlation between molecular changes in chromosome 17...
Source: Journal of the Anatomical Society of India - Category: Anatomy Source Type: research
CT lung screening may have added value in cancer detection beyond the chest,...Read more on AuntMinnie.comRelated Reading: PET/CT remains best option for head, neck cancer PET/CT after therapy avoids surgery for head, neck cancer Lung plus head/neck cancer screening delivers high yields PET/CT details hint at survival of head and neck cancer patients IMRT confers survival benefit for head and neck cancer
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
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