A method of elevated temperatures coupled with magnetic stirring to predict real time release from long acting progesterone PLGA microspheres

Publication date: Available online 14 August 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Mingzhu Ye, Hongliang Duan, Lixia Yao, Yicheng Fang, Xiaoyu Zhang, Ling Dong, Feifei Yang, Xinggang Yang, Weisan PanAbstractThe object of the study was to develop a quick and reproducible accelerated in vitro release method to predict and deduce the function of the real time (37 °C) release for long acting PLGA microspheres. The method could be described in several steps. First, the release of the microspheres were studied using the sample and separate method at 37 °C with normal orbital shaking and elevated temperatures with magnetic stirring to further accelerate the release. Second, the most similar profile at elevated temperatures with the real time release was chosen with the help of the n value in the fitted Korsmeyer-Peppas Function. Third, the Weibull function and conversion ratio were used to deduce the function of real time release according to the chosen profile at elevated temperatures. The key point in this study was to provide a quick and precise method to predict the real time release for long acting progesterone PLGA microspheres. So the elevated temperatures coupled with magnetic stirring were used to accelerate the release further, and when there have many similar release profiles with the real time release at elevated temperatures, releasing time at elevated temperatures and the R2 of the final deduced function will be used to help choosing the mo...
Source: Asian Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Source Type: research