The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity

Metidji et  al. show that deletion of Ahr in intestinal epithelial cells results in a defective barrier and unrestricted proliferation of intestinal stem cells (ISCs), culminating in malignant transformation. Activation of AHR by dietary ligands guards the ISC niche and maintains intestinal barrier homeostasi s.

Source: Immunity - August 14, 2018 Category: Allergy & Immunology Authors: Amina Metidji, Sara Omenetti, Stefania Crotta, Ying Li, Emma Nye, Ellie Ross, Vivian Li, Muralidhara R. Maradana, Chris Schiering, Brigitta Stockinger Tags: Article Source Type: research