The Kinase IKK β Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila

Goto et  al. show that the kinase dIKKβ and the NF-κB factor Relish control replication of picorna-like viruses in flies through induction of antiviral genes, including a homolog of STING. A STING-IKKβ-NF-κB cassette participates in resistance to picorna-like viruses, pointing to an evolutionarily anci ent role of STING in antiviral immunity.

Source: Immunity - August 14, 2018 Category: Allergy & Immunology Authors: Akira Goto, Kiyoshi Okado, Nelson Martins, Hua Cai, Vincent Barbier, Olivier Lamiable, Laurent Troxler, Estelle Santiago, Lauriane Kuhn, Donggi Paik, Neal Silverman, Andreas Holleufer, Rune Hartmann, Jiyong Liu, Tao Peng, Jules A. Hoffmann, Carine Meignin Tags: Article Source Type: research