Construction and characterization of a theranostic system based on graphene/manganese chelate.
Construction and characterization of a theranostic system based on graphene/manganese chelate.
Biosens Bioelectron. 2018 Oct 15;117:794-801
Authors: Karimi Shervedani R, Samiei Foroushani M, Kefayat A, Torabi M, Rahnemaye Rahsepar F
Abstract
Construction of hybrid systems that combine the cancer treatment and diagnosis agents on a single platform, known as theranostic systems, have received great attentions in the field of nanobiomedicine. Here, construction and characterization of a new multifunctional hybrid theranostic system based on RGO, PDA, BSA, DTPA-Mn(II), and MTX constituents, is presented. Accordingly, GO is partially reduced and simultaneously functionalized by dopamine, leading to reduced graphene oxide/polydopamine, RGO-PDA system; and then, the bovine serum albumin protein (BSA) is grafted onto this system. The obtained system, RGO-PDA-BSA, is further decorated with diethylenetriaminepentaacetic acid-Mn(II) as diagnostic system and methotrexate as anticancer drug. Physicochemical characteristics of the RGO-PDA-BSA-DTPA-Mn(II)/MTX system are studied by Fourier transform infrared spectroscopy, atomic force microscopy, and electrochemical methods. The capturing ability of the prepared system for the cancer cells is evaluated through electrochemical impedance spectroscopy (EIS) and by using the 4T1 cancer cells in comparison with L929 normal cells. The EIS results indicate that a degree of selectivity as 6.23 for GC-RGO-PD...
Source: Biosensors and Bioelectronics - Category: Biotechnology Authors: Karimi Shervedani R, Samiei Foroushani M, Kefayat A, Torabi M, Rahnemaye Rahsepar F Tags: Biosens Bioelectron Source Type: research
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