Lyme Disease Is Spreading Fast. Why Isn ’ t There a Vaccine?

The only vaccine was taken off the market more than 15 years ago. As reports of the disease skyrocket, researchers are working on a new one.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Ticks (Insects) Vaccination and Immunization Lyme Disease American Lyme Disease Foundation Plotkin, Stanley A Source Type: news

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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Prevention of Lyme disease in dogs in North America depends on effective vaccination against infection by the tick vector-born spirochete Borrelia burgdorferi. Most vaccines effectively prevent spirochete transmi...
Source: BMC Veterinary Research - Category: Veterinary Research Authors: Tags: Research article Source Type: research
In this study, we found that TXNIP deficiency induces accelerated senescent phenotypes of mouse embryonic fibroblast (MEF) cells under high glucose condition and that the induction of cellular ROS or AKT activation is critical for cellular senescence. Our results also revealed that TXNIP inhibits AKT activity by a direct interaction, which is upregulated by high glucose and H2O2 treatment. In addition, TXNIP knockout mice exhibited an increase in glucose uptake and aging-associated phenotypes including a decrease in energy metabolism and induction of cellular senescence and aging-associated gene expression. We propose that...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Why do only some older people develop the elevated levels of amyloid-β that start the amyloid cascade of Alzheimer's disease, leading to tau aggregation and consequent death and dysfunction of brain cells? If amyloid-β is the result of persistent infection by pathogens such as herpesviruses and lyme spirochetes that are, collectively, only present in 20% or so of the population, then perhaps that is the answer. This is the core of the microbial hypothesis of Alzheimer's disease, that amyloid-β is a feature of the innate immune system, and thus persistent infection of brain tissue will result in higher levels...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Listen: Mayo Clinic Radio 9/1/18 On the Mayo Clinic Radio podcast, Dr. Gregory Poland, director of Mayo Clinic's Vaccine Research Group, discuss vaccines for vector-borne illnesses, including Lyme disease and Zika virus. Dr. Poland also discusses the problem of vaccine hesitancy. Also on the podcast, Dr. Margaret Long, a gynecologist at Mayo Clinic, explains how [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
This study assessed cost-effectiveness of a potential anti-tick vaccine that would protect against both Lyme borreliosis (LB) and tick-borne encephalitis (TBE) in a highly endemic setting of Slovenia.A Markov model was developed to estimate cost-effectiveness of a vaccine with potential combined protection against LB and TBE from the societal perspective. The model expressed time in annual cycles, followed a target population through their lifetime, and applied an annual discounting of 3%. A target population entered the model in a susceptible state, with time dependent probabilities to acquire LB/TBE. Disease manifestatio...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
BOSTON (CBS) – More and more people are being afflicted by Lyme disease, not only here in New England but around the country. It begs the question, why don’t we have a vaccine to prevent this common tick-borne illness? A human vaccine was introduced in 1998. It was effective but expensive and there was public concern about its safety and sales were low, so it was yanked off the market four years later. Right now there is only a Lyme vaccine for dogs. Fortunately, there is a new vaccine for humans in the pipeline developed by a French company, which says it has received fast-track status from the FDA and hopes t...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated Local Watch Listen Dr. Mallika Marshall LYME DISEASE Source Type: news
In this study, we analyzed FGF21 levels and alterations in the expression of genes encoding components of the FGF21-responsive molecular machinery in adipose tissue from aged individuals so as to ascertain whether altered FGF21 responsiveness that develops with aging jeopardizes human health and/or accelerates metabolic disturbances associated with aging. We studied a cohort of 28 healthy elderly individuals (≥70 years) with no overt signs of metabolic or other pathologies and compared them with a cohort of 35 young healthy controls (≤40 years). Serum FGF21 levels were significantly increased in elderly indiv...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
LYME disease symptoms are not always obvious. While a rash is one of the most notable signs you ’ve been bitten by an infected tick, flu-like symptoms can also develop. There are ways of preventing the disease, but is a vaccine one of them?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The tick-borne pathogen Borrelia burgdorferi is responsible for approximately 300,000 Lyme disease (LD) cases per year in the United States. Recent increases in the number of LD cases, in addition to the spread of the tick vector and a lack of a vaccine, highlight an urgent need for designing and developing an efficacious LD vaccine. Identification of protective epitopes that could be used to develop a second-generation (subunit) vaccine is therefore imperative. Despite the antigenicity of several lipoproteins and integral outer membrane proteins (OMPs) on the B. burgdorferi surface, the spirochetes successfully evade anti...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Microbial Immunity and Vaccines Source Type: research
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