Clarithromycin as the empiric antibiotic therapy for medication-related osteonecrosis of the jaw in multiple myeloma patients

Medication-related osteonecrosis of the jaw (MRONJ) is a devastating adverse effect of several medications. In vast majority of cases, the offenders are bisphosphonates and denosumab which are given in metabolic bone diseases, bone metastases, hypercalcemia of malignancy, and multiple myeloma (MM). Most patients diagnosed with MRONJ are treated using antibiotics (about 60%) [1,2] and the courses are frequently long-term (even for over a year) [3].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Tags: Perspectives Source Type: research