Kynurenine Pathway Changes in Late-life Depression with Memory Deficit

Late-life depression (LLD) is the most common mental illness in old age, with a diagnosis in 0.04% to 13.4% of elderly individuals (Guerra, Prina, Ferri, Acosta, Gallardo, Huang et al., 2016) and is associated with a high cost of medical expenses and nursing (Donohue and Pincus, 2007). In addition, patients with LLD have a higher risk of developing cognitive deficit than those without depression (Yeh, Tsang, Lin, Kuo, Yen, Chen et al., 2011). Some authors have also proposed that LLD with cognitive deficit is a preclinical stage of Alzheimer's disease (AD) (Heser, Bleckwenn, Wiese, Mamone, Riedel-Heller, Stein et al., 2016).

Source: Psychiatry Research - August 13, 2018 Category: Psychiatry Authors: Yujie Wu, Naikeng Mai, Xiaomei Zhong, Yuguan Wen, Yanling Zhou, Haiyan Li, Dewei Shang, Lijun Hu, Xinru Chen, Ben Chen, Min Zhang, Yuping Ning Source Type: research