Biomarkers of dementia in obstructive sleep apnea

Epidemiologic and mechanistic evidence is increasingly supporting the notion that obstructive sleep apnea is a risk factor for dementia. Hence, the identification of patients at risk of cognitive decline due to obstructive sleep apnea may significantly improve preventive strategies and treatment decision-making. Cerebrospinal fluid and blood biomarkers obtained through genomic, proteomic and metabolomic approaches are improving the ability to predict incident dementia. Therefore, fluid biomarkers have the potential to predict vulnerability to neurodegeneration in individuals with obstructive sleep apnea, as well as deepen our understanding of pathophysiological processes linking obstructive sleep apnea and dementia.

Source: Sleep Medicine Reviews - August 13, 2018 Category: Sleep Medicine Authors: Andr ée-Ann Baril, Julie Carrier, Alexandre Lafrenière, Simon Warby, Judes Poirier, Ricardo S. Osorio, Najib Ayas, Marie-Pierre Dubé, Dominique Petit, Nadia Gosselin, Canadian Sleep and Circadian Network Tags: Clinical Review Source Type: research