Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii

AbstractNine new monomacrolide sesquiterpene pyridine alkaloids, macroregelines  A–I (1–9), were isolated from the stems ofTripterygium regelii, along with a known alkaloid, tripfordine  B. The structures of all the isolated compounds were characterized by extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic analyses, as well as high-resolution electrospray-ionization mass spectrometry (HRESIMS) data. Compounds4,5,6, and8 showed antiproliferative effect on human rheumatoid arthritis synovial cell line MH7A at concentration of 20  μM, reducing their viability by 7.5, 18.0, 9.0, and 18.2 %, respectively.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research