Overexpression of steroid receptor coactivators alleviates hyperglycemia-induced endothelial cell injury in rats through activating the PI3K/Akt pathway.

In conclusion, hyperglycemia decreased SRC-1 and SRC-3 expression levels in rat aortic endothelial cells. SRC-1 and SRC-3 overexpression might protect against endothelial injury via inhibition of oxidative stress and activation of PI3K/Akt pathway. PMID: 30089865 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30089865?dopt=Abstract

Source: Acta Pharmacologica Sinica - August 8, 2018 Category: Drugs & Pharmacology Authors: Quan XJ, Liang CL, Sun MZ, Zhang L, Li XL Tags: Acta Pharmacol Sin Source Type: research