Comparison of transcriptome responses to glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione in the HepaRG cell line

Publication date: Available online 11 August 2018Source: Toxicology ReportsAuthor(s): Robin Mesnage, Martina Biserni, Eva Wozniak, Theodoros Xenakis, Charles A Mein, Michael N AntoniouAbstractUse and thus exposure to quizalofop-p-ethyl, isoxaflutole, mesotrione and glyphosate, which are declared as active principles in commercial formulations of herbicides, is predicted to rapidly increase in coming years in an effort to overcome the wide-spread appearance of glyphosate-resistant weeds, especially in fields where glyphosate-tolerant genetically modified crops are cultivated in the USA. Thus, there is an urgent need for an evaluation of metabolic effects of new pesticide ingredients used to replace glyphosate. As the liver is a primary target of chemical pollutant toxicity, we have used the HepaRG human liver cell line as a model system to assess the toxicological insult from quizalofop-p-ethyl, isoxaflutole, mesotrione and glyphosate by determining alterations in the transcriptome caused by exposure to three concentrations of each of these compounds, including a low environmentally relevant dose. RNA-seq data were analysed with HISAT2, StringTie and Ballgown. Quizalofop-p-ethyl was found to be the most toxic of the pesticide ingredients tested, causing alterations in gene expression that are associated with pathways involved in fatty acid degradation and response to alcoholism. Isoxaflutole was less toxic, but caused detectable changes in retinol metabolism and in the PPAR si...
Source: Toxicology Reports - Category: Toxicology Source Type: research

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Publication date: Available online 21 October 2019Source: Food ChemistryAuthor(s): Olaf J. Schelezki, Guillaume Antalick, Katja Šuklje, David W. JefferyAbstractPre-fermentative juice substitution with water or early harvest wine has the potential to produce lower alcohol wines without critically modifying colour or tannin properties and only marginally changing volatile and sensory profiles. Whether this approach is suited to producing lower alcohol wines in the absence of excessive grape ripeness remained to be determined. The current study extends on pre-fermentative approaches to alcohol management under milder g...
Source: Food Chemistry - Category: Food Science Source Type: research
Publication date: Available online 21 October 2019Source: Journal of Molecular StructureAuthor(s): Gemma Leone, Marco Consumi, Simone Pepi, Alessio Pardini, Claudia Bonechi, Gabriella Tamasi, Alessandro Donati, Claudio Rossi, Agnese MagnaniAbstractPoly-vinyl alcohol (PVA) with different molecular weight (27 kDa, 31 kDa, 61 kDa, 125 kDa and 195 kDa) were phosphorylated with trisodium trimetaphosphate (STMP) or sodium hexa-metaphosphate (SHMP) working at pH 10 or 12. Strong chemical hydrogels (G’>G”) were obtained starting from polymers with higher MW (61 kDa, 125 kDa and 195 kDa). Infrared Spe...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: 15 December 2019Source: Journal of Molecular Liquids, Volume 296Author(s): Mahmoud Rahmati, Marjan Jangali, Hossein RezaeiAbstractThe conductivity and diffusion of hydronium ions at 298 K in PVA (Polyvinyl alcohol), PBI (Polybenzimidazole) and SPEEK (Sulfonated polyether ether ketone) as known membranes of PEMFCs have been investigated using molecular dynamics simulation method throughout this work. The simulation results show that the diffusion of hydronium ions in these polymer membranes depends on the polymer structure and water concentration in the membrane. On the other hand, RDF analysis results a...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
In this study, the gel bead was characterized using FTIR, XPS, SEM, EDS, and 13C NMR. The experimental data shows that there is a strong correlation between adsorption capacity. The adsorption data fitted well with the Freundlich isotherm model and the pseudo-second-order model. The results of thermodynamics show that the adsorption process is spontaneous, endothermic, and increases entropy. The maximum adsorption capacity for DS was calculated as 493.81 mg/g at pH 5 (308 K). The adsorbent still exhibited excellent adsorption capacity after recycling five times, showing it has excellent potential for practical applicat...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 21 October 2019Source: Microchemical JournalAuthor(s): Binbin Guan, Zhaoli Xue, Quansheng Chen, Hao Lin, Jiewen ZhaoAbstractThis work presents a real-time ethanol content measurement method during the solid-state fermentation of “Zhenjiang” Aromatic vinegar. 5, 10, 15, 20-Tetraphenyl-21H, 23H-porphine zinc (ZnTPP) which was sensitive to ethanol was employed to capture VOC from semi-solid state vinegar during fermentation. Various self-assembled nanostructures of ZnTPP based was be synthesized, while the effect of aging time and the pH on the morphology of nanoporphyrin has bee...
Source: Microchemical Journal - Category: Chemistry Source Type: research
CrystEngComm, 2019, Accepted Manuscript DOI: 10.1039/C9CE00965E, PaperJinyao Chen, Wenming Zhu, Weijie Ji, Bin Zhu, Chunyang Guo, Ming-Hui Qi, Guo-Bin Ren During a comprehensive structure and stability study on the hydrates and alcohol solvates of pharmaceutical molecule ginsenoside compound K (20-O- β-glucopyranosyl-20(S)-protopanaxadiol, GCK), the crystal structure of hemihydrate (HH), ethanol solvate (SEt)... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - CrystEngComm latest articles - Category: Chemistry Authors: Source Type: research
Condition:   Alcohol Use Disorder Intervention:   Device: transcranial direct current stimulation Sponsors:   Shanghai Mental Health Center;   Wuhan Union Hospital, China Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 22 October 2019Source: Social Science &MedicineAuthor(s): Abigail M. Hatcher, Andrew Gibbs, Ruari McBride, Dumisani Rebombo, Mzwakhe Khumalo, Nicola ChristofidesAbstractMen whose sexual behaviors place them at risk of HIV often exhibit a “cluster” of behaviors, including alcohol misuse and violence against women. Called the “Substance Abuse, Violence and AIDS (SAVA) syndemic,” this intersecting set of issues is poorly understood among heterosexual men in sub-Saharan Africa. We aim to determine cross-sectional associations between men's use of alcohol, violence,...
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 22 October 2019Source: International Journal of PsychophysiologyAuthor(s): Andrés Martínez-Maldonado, Rosa Jurado-Barba, Ana Sion, Isabel Domínguez-Centeno, Gabriela Castillo-Parra, Julio Prieto-Montalvo, Gabriel RubioAbstractThe use of the cognitive-bias modification (CBM) method has emerged as a therapeutic complement in the treatment of alcoholism, producing changes at behavioral and brain level. Nevertheless, the impact of the CBM procedure could be improved by the memory retrieval-extinction process (REP). Different studies have demonstrated that the retrieval of...
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
RESUMO Objetivo O estudo prop ôs-se a avaliar diferentes domínios das funções executivas em adolescentes como preditores ao uso de álcool e cigarro. Métodos Utilizou-se um delineamento transversal. A amostra foi composta por 239 adolescentes com idade média de 15,34 (±2,32). Os testes Alcohol Use Disorders Identificati on Test (AUDIT) e Fagerstrom Test for Nicotine Dependence (FTND) avaliaram o uso de álcool e cigarro respectivamente. O Self-Reporting Questionnaire (SRQ-20) foi utilizado para rastreio de saúde mental. Os testes Iowa Gambling Task (IGT), W...
Source: Jornal Brasileiro de Psiquiatria - Category: Psychiatry Source Type: research
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