Subjugation of TGF β Signaling by Human Papilloma Virus in Head and Neck Squamous Cell Carcinoma Shifts DNA Repair from Homologous Recombination to Alternative End-Joining.

CONCLUSIONS: HPV-positive HNSCC cells are unresponsive to TGFβ. Abrogated TGFβ signaling compromises homologous recombination and shifts reliance on alt-EJ repair that provides a mechanistic basis for sensitivity to PARP inhibitors. The effect of HPV in HNSCC provides critical validation of TGFβ's role in DNA repair proficiency and further raises the translational potential of TGFβ inhibitors in cancer therapy. PMID: 30087144 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30087144?dopt=Abstract

Source: Clinical Cancer Research - August 7, 2018 Category: Cancer & Oncology Authors: Liu Q, Ma L, Jones T, Palomero L, Pujana MA, Martinez-Ruiz H, Ha PK, Murnane J, Cuartas I, Seoane J, Baumann M, Linge A, Barcellos-Hoff MH Tags: Clin Cancer Res Source Type: research