Differential associations between appendicular and axial marrow adipose tissue with bone microarchitecture in adolescents and young adults with obesity

Marrow adipose tissue (MAT) in humans is distributed differentially across age and skeletal site. We have shown impaired microarchitecture and reduced bone strength at appendicular sites in conditions associated with high MAT of the axial skeleton in adults (including conditions of over- and undernutrition). Data are lacking regarding differences in MAT content of the appendicular versus the axial skeleton, and its relationship with bone microarchitecture and strength. Furthermore, data are conspicuously lacking in adolescents, a time when hematopoietic marrow is progressively converted to fatty marrow.
Source: Bone - Category: Orthopaedics Authors: Tags: Rapid Communication Source Type: research