Breast Cancer Stem Cells and Sex Steroid Hormones.

Breast Cancer Stem Cells and Sex Steroid Hormones. Curr Stem Cell Res Ther. 2018 Aug 10;: Authors: Flores-Ramirez I, Baranda-Avila N, Langley E Abstract Breast cancer stem cells (BCSCs) are a small population of tumor-initiating cells that express stem cell-associated markers. In recent years, their properties and mechanisms of regulation have become a focus for intense research due to their intrinsic resistance to conventional cancer therapies. This review describes breast cancer stem cell origin, signaling pathways involved in self-renewal, such as Wnt, Notch and Hedgehog, biomarkers linked to stemness, and the role of sex steroid hormones on BCSC regulation. PMID: 30095060 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research