A Missing Link: Sarcoid-lymphoma syndrome

When the patient's autoimmune disorder didn't respond to treatment, an additional workup uncovered a malignancy; one with an undefined connection. A 73-year-old woman presented with fatigue, left upper quadrant pain, headache, nausea, and cognitive dysfunction. An initial workup revealed  hypercalcemia, a low level of parathyroid hormone, elevated levels of angiotensin converting enzyme and alkaline phosphatase, pancytopenia, and mediastinal lymphadenopathy (Table 1). While magnetic resonance imaging (MRI) of her brain produced unremarkable results, abdominal imaging showed tra ce ascites, mild splenomegaly with calcified granulomas, and borderline hepatomegaly.
Source: The American Journal of Medicine - Category: General Medicine Authors: Source Type: research