Hematopoietic cell transplantation for acute panmyelosis with myelofibrosis: a retrospective study in Japan

Acute panmyelosis with myelofibrosis (APMF) is a rare subtype of acute myeloid leukemia (AML) in the World Health Organization classification [1]. APMF is characterized by acute onset of cytopenias and bone marrow fibrosis in the absence of splenomegaly [2 –5]. A standard treatment has not been established for APMF. Treatment modalities for APMF have considerable heterogeneity, including chemotherapies such as danazol, lenalidomide, and zoledronate [2,3,6,7]. However, such treatments have limited efficacy and the vast majority of patients will die f rom progressive disease, such as bone marrow failure and development of overt AML.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: Brief Article Source Type: research