High prevalence of triazole resistance in clinical Aspergillus fumigatus isolates in a specialist cardio-thoracic centre

Aspergillus fumigatus is a ubiquitous ascomycete mould that can cause a wide spectrum of clinical syndromes. The pathological effects of A. fumigatus depend largely on the interplay between the pathogen and host immune response ranging from asymptomatic colonisation to life-threatening infection. Invasive aspergillosis (IA), the most severe form of A. fumigatus infection, predominantly affects immunocompromised patients. In contrast, immune hyperactivity can lead to allergic bronchopulmonary aspergillosis (ABPA) and fungal sensitization in severe asthma (SAFS).
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research