Acute heart rate-dependent hemodynamic function of the heart in the post-myocardial infarction rat model: change over time

ConclusionsIn a rat HF model, optimal HR with regard to acute hemodynamic performance is shifted. While in ShO rats increased HR facilitates CO increase induced by PI, in HF rats such increase reduces CO, while HR reduction has beneficial effects. Thus besides reducing progression of HF, HR-reducing interventions also offer immediate hemodynamic benefits.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research